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mugecevik's profile
Muge Cevik
Muge Cevik
Muge Cevik
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@mugecevik

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Muge CevikVerified account

@mugecevik

Clinician Scientist • Infectious Diseases / Virology @univofstandrews • publichealth, TB, HIV • #vegan🌱• #FaceTheClimateEmergency • RT ≠ endorsement

Edinburgh, Scotland
scholar.google.com/scholar?as_ylo…
Joined August 2009

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    1. Muge Cevik‏Verified account @mugecevik 15 Dec 2021

      Very interesting analyses about the virology of #Omicron, which may explain the faster spread of this variant. According to a new lab study, Omicron infects & multiplies ~70x faster than the Delta variant and the wild type SARS-CoV-2 in the human bronchus, but not in the lung.

      364 replies 5,113 retweets 12,827 likes
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      Muge Cevik‏Verified account @mugecevik 15 Dec 2021

      In this ex vivo study (press release), Michael Chan, Malik Peiris & John Nicholls et al. @hkumed show that at 24h after infection Omicron replicated ~70x faster than Delta in bronchus. Interestingly, it replicated ~10x less efficiently in the lung tissue. https://hkumed.hk/96b127 /pic.twitter.com/3NoQOFFB8D

      4:05 AM - 15 Dec 2021
      • 804 Retweets
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      • Schilz Gaby The Perceptor MSc. clinicalstrength Jimmy John JSDThompson Iwantpeace El Demiurgo MarkQuarter anamai
      HKU Public Health and HKU Medicine
      69 replies 804 retweets 2,600 likes
        1. New conversation
        2. Muge Cevik‏Verified account @mugecevik 15 Dec 2021

          Another analysis by @BalazsLab also supports these findings. In this lab study w/ pseudoviruses, Omicron showed greater ability to infect cells than other variants, which was ~ 4 times more infectious than the original strain, also more than Delta. https://www.medrxiv.org/content/10.1101/2021.12.14.21267755v1/ …pic.twitter.com/0fKoAE2LfX

          15 replies 298 retweets 1,413 likes
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        3. Muge Cevik‏Verified account @mugecevik 15 Dec 2021

          These preliminary laboratory analyses indicate that; 📍Omicron is significantly more transmissible than delta 📍Less efficient replication in the lungs may suggest lower severity, but severity in humans is not determined only by virus replication but also the host immune response

          53 replies 820 retweets 3,664 likes
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        4. Muge Cevik‏Verified account @mugecevik 15 Dec 2021

          Important to note that first study is an ex vivo work, meaning that human tissue is used to look at virus replication in the lab. So, this is not a definitive but supportive finding & needs to be confirmed by clinical data as host immune response is absent in these studies.

          9 replies 223 retweets 1,793 likes
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        5. Muge Cevik‏Verified account @mugecevik 15 Dec 2021

          Muge Cevik Retweeted Muge Cevik

          Lay summary: These results indicate inherent transmissibility & replication advantage of Omicron (in addition to immune evasion) compared to delta. It also explains why it spreads quickly and outcompeted delta in SA, which fits w/ modelling assumptions.https://twitter.com/mugecevik/status/1466845357686640640?s=20 …

          Muge Cevik added,

          Muge CevikVerified account @mugecevik
          🦠 There’s a lot we don’t yet understand about Omicron, including its impact on immunity and what it means for vaccines. New data will be emerging over the next few wks, which could be misinterpreted w/o context. What we might expect & how to interpret the emerging data? 🧵(1/n)
          Show this thread
          26 replies 294 retweets 1,528 likes
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        6. Muge Cevik‏Verified account @mugecevik 15 Dec 2021

          For those asking whether this is good/bad news, simple answer: I don't know. While omicron may infect the lung cells less efficiently, a higher viral load may worsen immune response. We discussed the pathogenesis w/ @KindrachukJason @KrutikaKuppallihttps://www.bmj.com/content/371/bmj.m3862 …

          26 replies 407 retweets 1,829 likes
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        7. Muge Cevik‏Verified account @mugecevik 15 Dec 2021

          Muge Cevik Retweeted Muge Cevik

          The only thing I am sure of is that omicron will spread so quickly through the population, making it likely impossible to contain even with the most stringent measures & giving us very little time over the next few weeks. So get your vaccines & boosters!https://twitter.com/mugecevik/status/1468518680157999106?s=20 …

          Muge Cevik added,

          Muge CevikVerified account @mugecevik
          Yes, we may need omicron specific vaccines, esp if omicron is to outcompete delta globally, which we don't know yet. But, at present Delta remains the dominant variant globally. So, don't wait for an updated vaccine, get your primary 2 doses and/or booster dose immediately.
          Show this thread
          163 replies 874 retweets 2,557 likes
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        8. End of conversation
        1. Jens Nordvig‏ @jnordvig 15 Dec 2021
          Replying to @mugecevik @hkumed @HKU_SPH

          Can we assume that the study is done in lung tissue with 'no immunity' from natural or vaccine induced immunity? (there is no detail in the write-up I can see) Thanks in advance

          1 reply 0 retweets 2 likes
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        2. Jason Pogue‏ @jpogue1 15 Dec 2021
          Replying to @mugecevik @hkumed @HKU_SPH

          Notable that the 10x number is compared to the original and not delta - and that there is no significant difference compared to delta (which wasn‘t less severe than the original). Still hopeful, but don’t love the different comparisons in the two. Thanks for sharing!

          1 reply 1 retweet 7 likes
        3. Jono‏ @quinn_jono 15 Dec 2021
          Replying to @jpogue1 @mugecevik and

          The graph posted above clearly shows Omicron at 10x both the original and delta variants at 24 hours. Are you referring to a different graph?

          1 reply 0 retweets 3 likes
        4. End of conversation
        1. Dr John Tregoning‏ @DrTregoning 15 Dec 2021
          Replying to @mugecevik @hkumed @HKU_SPH

          Mechanistically, why would changes in spike affect the speed of replication? More in/more out? More cells hit simultaneously?

          2 replies 0 retweets 2 likes
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