Andrew Morton

@morton_andrew

CWRU MD-PhD Student and Rich lab

Cleveland, OH
Vrijeme pridruživanja: svibanj 2011.

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  1. Prikvačeni tweet
    27. stu 2019.

    Here’s a link to read and download for those without a subscription. Check it out!

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  2. proslijedio/la je Tweet

    Don't Panic! If you have ATAC-seq data and you're not sure of the best way to analyze it , and co have written a review to help you. You'll soon know where your towel is.

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  3. proslijedio/la je Tweet
    3. velj

    I love Super Bowl statistics. (“No team that has failed to convert at least 35% of their 3rd downs has gone on to win” etc.) They are the best introduction to p-hacking that can be found outside major journals.

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  4. proslijedio/la je Tweet
    31. sij

    Excited to announce the latest extension of CoGAPS for scATAC-seq led by the great Rossin Erbe! Matrix factorization and transfer learning uncover regulatory biology across multiple single-cell ATAC-seq data sets | bioRxiv

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  6. proslijedio/la je Tweet
    28. sij

    We wrote the review that I wished I'd had when I started my PhD in gene regulation & genomics! Read for our take on the past 40 yrs of enhancer biology, a def of an "enhancer", and how we think modern tech (like CRISPR screens) will enable the next era of understanding the genome

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  7. proslijedio/la je Tweet
    27. sij

    Inspired by recent tweet on the "80/20" challenge of the physician scientist () my two cents. Worklife balance to be discussed another time ...

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  8. proslijedio/la je Tweet
    24. sij

    Our preprint on AmpliconReconstructor, which reconstructs complex amplifications in cancer - leveraging optical mapping and WGS data is out now! We show megabase-scale reconstructions of circular , a 10+ Mbp breakage fusion bridge, and more.

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  9. proslijedio/la je Tweet
    23. sij

    Our collaborative work with the Pasca lab mapping the chromatin accessibilty dynamics of human forebrain development just came out! Congrats to Alex, Nasa, and Jimena!

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  10. proslijedio/la je Tweet
    23. sij

    My team's latest publication deepening our understanding of the noncoding cancer genome: Noncoding mutations target cis -regulatory elements of the FOXA1 plexus in prostate cancer

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    20. sij

    I am very excited to share our latest work on candidate non-coding cancer driver mutations published in /w et al Thread: /17

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  12. proslijedio/la je Tweet
    16. sij

    Another beauty on mechanisms of focal genomic instability from the Pellman lab:

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  13. proslijedio/la je Tweet
    7. sij

    The prospective clinical MSKCC NGS cohort is now >50,000 samples sequenced. Thanks to the hundreds of physicians, laboratory technicians, data scientists, nurses and support staff who have made this initiative possible. A few thoughts on what we have learned.

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  14. proslijedio/la je Tweet
    7. sij

    Our latest using single-cell ATAC-seq and HiChIP to identify putative functional risk loci in Alzheimer’s and Parkinson’s disease. This was an amazing collaboration between and the twitterless Tom Montine. 1/n

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  15. proslijedio/la je Tweet
    16. pro 2019.

    Preprint alert! We are excited to share our latest work that uncovers key differences in the gene regulatory landscape between naïve and primed human pluripotent stem cells. 1/5

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  16. proslijedio/la je Tweet
    16. pro 2019.

    Check out our paper, online today ! With Richard Koche , from the Torrents lab and colleagues , we describe that circular DNA serves as a substrate for oncogenic genome remodelling

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  17. proslijedio/la je Tweet
    16. pro 2019.

    Stochastic dynamics of extra-chromosomal DNA. Work with and on a fascinating aspect of cancer evolution. Shortest summary: The evolutionary dynamics differs a lot compared to classic somatic evolution of SNVs.

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    My favorite papers challenge biomedical dogma. Here's my summary of the ones in 2019 that provided evidentiary shakeups (2nd annual list) [let me know the ones I missed]

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    1/7 In this new preprint we investigated how CTCF controls genome folding. TLDR: it’s about the CTCF N-terminus. Collaborative work between lab of , (Maxime Dahan lab), (Katherine Pollard lab)

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  20. proslijedio/la je Tweet
    6. pro 2019.

    Very excited that our paper on the embryonic origins of childhood kidney cancer is out! Read all about it here:

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