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mlipsitch's profile
Marc Lipsitch
Marc Lipsitch
Marc Lipsitch
@mlipsitch

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Marc Lipsitch

@mlipsitch

Infectious disease epidemiologist and microbiologist, aspirational barista. mlipsitc@hsph.harvard.edu Director @CCDD_HSPH

Boston, MA
hsph.harvard.edu/faculty/marc-l…
Joined September 2009

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    1. Eric Feigl-Ding‏ @DrEricDing Jan 31

      Eric Feigl-Ding Retweeted Trevor Bedford

      25. QUICK FOLLOWUP: One researcher @trvrb did a BLAST search and did find the insertions existing in other related viruses. Let’s wait and see for more confirming / refuting studies to be published. https://twitter.com/trvrb/status/1223337991168380928?s=21 …https://twitter.com/trvrb/status/1223337991168380928 …

      Eric Feigl-Ding added,

      Trevor Bedford @trvrb
      These short inserts do indeed exist in #nCoV2019 relative to its closest sequenced relative (BetaCoV/bat/Yunnan/RaTG13/2013, seen here https://nextstrain.org/groups/blab/sars-like-cov …). However, a simple BLAST of such short sequences shows match to a huge variety of organisms. No reason to conclude HIV. https://twitter.com/biorxivpreprint/status/1223245639296978951 … pic.twitter.com/mUfxwB6GsP
      Show this thread
      28 replies . 232 retweets 510 likes
      Show this thread
    2. Laura Holst‏ @LauraHolst Jan 31
      Replying to @DrEricDing @trvrb

      I could be wrong, but in reading the paper out of ITT Delhi it looks to me that they were not saying that there weren't other BLAST matches but rather that the only one all 4 inserts had in common was HIV-1. 3 of them gp120 and 1 gag. Am I incorrect?

      3 replies . 3 retweets 20 likes
    3. Laura Holst‏ @LauraHolst Jan 31
      Replying to @LauraHolst @DrEricDing @trvrb

      @asrayagiriraj Thanks for the "like" and the confirmation. I hope you and your colleagues are addressing the scientific critique with those scientists. :) Thank you for adding to our knowledge base.

      2 replies . 2 retweets 5 likes
    4. Ashutosh Kumar Pandey‏ @asrayagiriraj Jan 31
      Replying to @LauraHolst @DrEricDing @trvrb

      1/3 Hi Laura. You have actually captured the point we wanted to make. This probability of having 4 inserts becomes even more improbable if the data about the function of the domains in both 2019-nCoV and HIV, where these inserts are similar, are compared.

      1 reply . 7 retweets 19 likes
    5. Ashutosh Kumar Pandey‏ @asrayagiriraj Jan 31
      Replying to @asrayagiriraj @LauraHolst and

      2/3 Added to this , what is the probability that they all have similar physicochemical properties and every deletion in nCoV as compared to HIV actually brings the pI values closer? Add one more to this combined probability of all these inserts folding into

      1 reply . 4 retweets 10 likes
    6. Ashutosh Kumar Pandey‏ @asrayagiriraj Jan 31
      Replying to @asrayagiriraj @LauraHolst and

      a common function domain? There are too many coincidences. What we didn't mention in the paper is that the insert that comes from Gag protein is actually very close to p24 domain, which is involved in vesicle binding.

      2 replies . 4 retweets 9 likes
    7. Ashutosh Kumar Pandey‏ @asrayagiriraj Jan 31
      Replying to @asrayagiriraj @LauraHolst and

      We are collecting all the critic, and will reply them in our peer review.

      6 replies . 3 retweets 19 likes
      Marc Lipsitch‏ @mlipsitch Jan 31
      Replying to @DrEricDing @asrayagiriraj and

      No I don't. @DrEricDing does not speak for me, or for @Harvard or for @HarvardChanSPH or for @HarvardEpi. He has a temporary appointment in our department of nutrition, is not an expert on viruses or evolution, and is seeking publicity not scientific dialogue.

      3:26 pm - 31 Jan 2020
      • 45 Retweets
      • 174 Likes
      • mikey Iron Feliks 🗡️ David H. Clements HALLYU WEBSITE Soma Xenophon Swift Brandon Tatum Marsh Ray m rose
      9 replies . 45 retweets 174 likes
        1. New conversation
        2. Marc Lipsitch‏ @mlipsitch Jan 31
          Replying to @mlipsitch @DrEricDing and

          temporary, visiting appointment, not a faculty member, not someone people should be treating as an expert in anything related to this coronavirus outbreak.

          7 replies . 7 retweets 63 likes
        3. 5 more replies
        1. New conversation
        2. Laura Holst‏ @LauraHolst Jan 31
          Replying to @mlipsitch @DrEricDing and

          Hmmm. PhD's in Epidemiology & Nutrition from Harvard w/ a minor in Biostatistics means he can't be trusted and knows nothing about the subject? I would kindly suggest that there is such a thing as RESPECTFUL disagreement amongst colleagues. You don't like his approach. Got it.

          3 replies . 0 retweets 9 likes
        3. Marc Lipsitch‏ @mlipsitch Jan 31
          Replying to @LauraHolst @DrEricDing and

          Respectful scientists don’t claim to speak for ppl they don’t know

          2 replies . 2 retweets 38 likes
        4. 9 more replies
        1. New conversation
        2. Alex Velencoso‏ @AlexVelencoso Jan 31
          Replying to @mlipsitch @DrEricDing and

          Hahahahaha Marc sounds stupid and angry because the newspapers are not looking for him to ask him questions 😂 but what would he expect after not publishing anything relevant during the last few years 😂😂😂

          1 reply . 1 retweet 3 likes
        3. Dr. Saskia Popescu‏ @SaskiaPopescu Jan 31
          Replying to @AlexVelencoso @mlipsitch and

          Bahahaha nice try. 🙄

          0 replies . 0 retweets 6 likes
        4. End of conversation
        1. New conversation
        2. 15 Scotland Tce‏ @RayJack17 Jan 31
          Replying to @mlipsitch @Ryan_Mac_Phd and

          Hi Ryan have you seen the zerohedge website conspiracy theory on how the virus was released. Any thoughts? Seems unlikely.

          1 reply . 0 retweets 0 likes
        3. 2 more replies
        1. New conversation
        2.  ☣️ Michael Ç̸̠͎͉̹̼̠͔̗̓̐̐̓̓̀͝͝. Bazaco  ☣️‏ @MCBazacoPhD Jan 31
          Replying to @mlipsitch @DrEricDing and

          Thank you. Public health and infectious disease researchers everywhere thank you for this.

          1 reply . 1 retweet 14 likes
        3. 3 more replies

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