Mike McLaren

@mikemc423

Microbiome analyzer and methods developer

Raleigh, NC
Vrijeme pridruživanja: srpanj 2015.

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  1. Prikvačeni tweet
    26. ruj 2019.

    Two weeks ago, the first paper from my postdoc with (and in collaboration with ) was published in at . It is a long one, so here is a summary!

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  2. proslijedio/la je Tweet
    29. sij

    Since I first read it, I've never stopped thinking about "The Natural Selection of Bad Science" The paper demonstrates better than any other how science reform is more about restructuring incentives than winning logical arguments

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  3. proslijedio/la je Tweet
    30. sij

    Sharing my step-by-step but concise notes on how to submit amplicon sequences to NCBI's SRA, in case it's helpful to others:

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  4. 28. sij

    I'm still honoring "stringsAsFactors" government of tax strings -> factors to match phyloseq's behavior, but considering forcing the user to ask for factor conversion explicitly in next version. Would love to hear thoughts on this.

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  5. 28. sij

    Speedyseq v0.1.1 now gives psmelt() another 2X speedup (~ 200X faster than phyloseq)

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  6. 18. sij

    Non-adaptive explanations I've imagined include evolved dependence of host on the commensal, or an immune against all microbes the commensals have evolved resistance to

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  7. 18. sij

    Reviews I've seen describe the "how" but seem uninterested in the "why". Would appreciate references to any discussion on this point!

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  8. 18. sij

    Why (in an evolutionary sense) would a host's response to _pathogens_ depend on the presence of _commensals_ in this way?

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  9. 18. sij

    or showing that commensals or their products are needed for development of the immune system or other pathogen defense

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  10. 18. sij

    Many studies describe cases where a host immune response against a pathogen is triggered by a commensal microbe

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  11. 18. sij

    twitter, a puzzle for you

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  12. 18. sij

    Thinking maybe someone has done this via WGS metagenome annotation

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  13. 18. sij

    Has anyone come across or attempted an estimate of the number of distinct microbe-microbe weapons systems in a single plant or human ?

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  14. proslijedio/la je Tweet
    2. sij

    Happy 2020! With the holidays behind us, wanted to highlight a few key take-aways from our preprint: . Our study focuses on a basic question: how do gut microbial communities respond to routine antibiotic treatments?

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  15. 18. pro 2019.

    includes a nice shout out to the Callahan lab too :)

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  16. proslijedio/la je Tweet
    17. pro 2019.

    So happy to see this paper led by out in ! We show that rare microbial taxa emerge during community coalescence and drive the maintenance of microbial functions and diversity. With

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  17. proslijedio/la je Tweet
    16. pro 2019.

    Finally it is done... SILVA 138 SSU is released. LSU will follow in Spring 2020. Please note: The Treeviewer and SILVAngs are still on SILVA 132. Updates are planned for January 2020. Many thanks for your patience, the next release will come faster 😉. The SILVA Team

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  18. proslijedio/la je Tweet
    16. pro 2019.

    This episode of the show is muy muy bueno: "…the interview, at over 4.5 hours long, outlines each current answer to the mystery of consciousness, what it has going for it, and its likely ethical implications."

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  19. proslijedio/la je Tweet
    15. pro 2019.

    It's a beautiful Sunday morning in Seattle 16S profiling provides relative abundance of reads attributed to taxa, which is not the same as the relative abundance of the taxa themselves.

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  20. proslijedio/la je Tweet
    16. pro 2019.

    Introducing... the Stat Div Lab blog! Our first post: "Microbiome data analysis 101" -- basic principles for reasonable analysis. Enjoy! 😺🎁💌🎄

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