Basically you need a RNA vaccine at some time to prime a wide B cell population for antibodies against variants. J&J does not substitute. If you don't do it earlier, you'll just have to do it later. I hope for the health of JnJers that @CDCgov and @CDCDirector will consider it.
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And vulnerable 2xRNA-vaccinated can schedule that 3rd dose before 6mo by declaring themselves immunocompromised. This policy was from back when Pfizer+Moderna's studies found a need, while J&J didn't do studies although JJ was even less protective.https://www.cdc.gov/coronavirus/2019-ncov/vaccines/recommendations/immuno.html …
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I get asked whether to get 100mcg Moderna (original dose), 50mcg Moderna (booster), or 30mcg Pfizer (original and booster). As mentioned below, you'd expect 100>50>30 in potency since RNA is RNA. But some people asked if diffs in the lipid carriers matter.https://twitter.com/michaelzlin/status/1466492316542111749 …
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Moderna found 100mcg and 50mcg Moderna 3rd doses raise nAb levels against Omicron by 87x and 37x respectively. Pfizer found its 30mcg booster raises nAbs by 25x. The Mod and Pfizer results are in different studies but so far it seems 100>50>30 indeed.https://www.telegraph.co.uk/global-health/science-and-disease/reassuring-moderna-booster-jab-triggers-strong-response-against/ …
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Many are wondering if they can boost earlier than 6mo. The NIH heterologous boost study used 3mo after initial series (1xJJ or 2xRNA). Pfizer tested 8mo after 2xRNA. Results were similar, suggesting 3-8mo all ok. CDC guided 6mo because immunity waned to <50% VE against Delta then
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And now Israel is allowing boosters 3mo after the previous shot. This will allow those 3mo out from last shot to get boosted ahead of winter, whereas earlier you had to wait for 6mos.https://www.usnews.com/news/health-news/articles/2021-12-27/live-updates-israel-trials-4th-dose-of-covid-19-vaccine …
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And yet CDC is maintaining initial J&J + 1 addl dose is fine. Which doesn’t make sense to me, but just a lay person here…
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You are a highly informed, well read, smart "lay person" and spot on about not making sense.
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So I got J&J in March.Took it upon myself to get full dose Moderna in late June.If I understand this correctly, I should get a booster, Moderna (half dose),in late December.(But finding a pharmacy will be difficult b/c of cdc not recommending it.) Thank you!
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I got a J&J in April, a Pfizer in July (in another state), then a full-dose Moderna end of November back in my home state. This was obviously not planned in advance but looks like a solid regimen in retrospect
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Halo! you can read it here: An important study just posted from
@BalazsLab Findings are good for… https://threadreaderapp.com/thread/1470798236919025665.html … Have a good day.
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Molecular engineering for voltage, viruses, and SARSCoV2. Fan of facts.