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michaelmina_lab's profile
Michael Mina
Michael Mina
Michael Mina
Verified account
@michaelmina_lab

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Michael MinaVerified account

@michaelmina_lab

Epidemiologist, Immunologist, Physician, Harvard Public Health/Medical School. Discuss vaccines, immunity, infectious diseases, public health, and tests

Boston, MA
Joined February 2019

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    Michael Mina‏Verified account @michaelmina_lab 18 Sep 2020

    Michael Mina Retweeted Covidpath

    PCR positive for #COVID19 does not mean you are infectious It means you have virus RNA Like DNA left at a crime scene, it doesn’t mean the virus is still there Virologists cautioned about equating PCR to live virus since the start of the “molecular revolution” in clinical labshttps://twitter.com/covidpath/status/1296959950808158209 …

    Michael Mina added,

    Covidpath @covidpath
    Thread about the difference between someone testing ​PCR ‘positive’ versus being contagious. Illustration from @michaelmina_lab: pic.twitter.com/fC1pSIrIIE
    Show this thread
    3:52 PM - 18 Sep 2020
    • 462 Retweets
    • 976 Likes
    • Stone Cold Pillar aungkan nk Hannes Ullrich Reg Reader 🇺🇸😷 💉 BABS Thomas 🧹🧹 annika Dark D Bert Macklin
    42 replies 462 retweets 976 likes
      1. New conversation
      2. Michael Mina‏Verified account @michaelmina_lab 18 Sep 2020

        Michael Mina Retweeted Michael Mina

        Why is this important? Read the thread by @covidpath 👆 and I explain a bit more here 👇https://twitter.com/michaelmina_lab/status/1296690611685404672 …

        Michael Mina added,

        Michael MinaVerified account @michaelmina_lab
        So much focus on sensitivity of the test. As though all tests must match up to PCR But could focusing so much on achieving the greatest molecular sensitivity for asymptomatic testing *when testing is infrequent* be doing more harm than good? I’ll explain 1/
        Show this thread
        2 replies 15 retweets 49 likes
        Show this thread
      3. Michael Mina‏Verified account @michaelmina_lab 18 Sep 2020

        To clarify the top tweet, it COULD mean you are infectious, but might not. A PCR with a very low Ct value means you are very likely infectious, should be isolated and contacts traced. Interpreting the Ct value is extremely helpful at the low Ct (high viral load) values to triage

        10 replies 18 retweets 98 likes
        Show this thread
      4. Michael Mina‏Verified account @michaelmina_lab 18 Sep 2020

        This is a terrific report on this issue from S Korea.https://www.cdc.go.kr/board/board.es?mid=a30402000000&bid=0030&act=view&list_no=367267&nPage=1 …

        1 reply 12 retweets 36 likes
        Show this thread
      5. End of conversation
      1. New conversation
      2. Nick m‏ @nicmoure_m 18 Sep 2020
        Replying to @michaelmina_lab

        That’s why need #sonananotech 100% accurate for asymptomatic people .best rapid test out there

        1 reply 1 retweet 1 like
      3. Michael Mina‏Verified account @michaelmina_lab 18 Sep 2020
        Replying to @nicmoure_m

        Hi. I worry that saying it is 100% isn’t helpful. No lab test is 100%. And certainly not an antigen test. A lot of investors invested in Sona. Not a bad thing, but the 100% accurate claim just doesn’t help Sona. I think it may raise the level of skepticism.

        2 replies 1 retweet 19 likes
      4. Show replies
      1. New conversation
      2. Nolan "#MaskUp #BLM " Kagetsu 花月, MD, (he/his)‏Verified account @nkagetsu 18 Sep 2020
        Replying to @michaelmina_lab

        Do all infectious folks have positive PCR? Can PCR be useful in finding asymptomatic/presymptomatic folks?

        1 reply 0 retweets 3 likes
      3. Michael Mina‏Verified account @michaelmina_lab 18 Sep 2020
        Replying to @nkagetsu

        Absolutely it can. Has to be done with care though. A repeat test of a positive at 24 hours later can be extremely informative to know if you are picking up low viral load in pre/asymptomatics before transmissible, or, more likely, too late, after transmission has ended.

        1 reply 0 retweets 6 likes
      4. Show replies
      1. Rob Lipton‏ @wiremother 18 Sep 2020
        Replying to @michaelmina_lab

        Really important point, that's why your push for quick and dirty and constant lateral flow testing is the bomb

        0 replies 0 retweets 4 likes
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      1. LucyLou  🙂‏ @Lucy26398575 18 Sep 2020
        Replying to @michaelmina_lab

        Great graphic...thanks for posting

        0 replies 0 retweets 3 likes
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      2. Ventnostics‏ @ventnostics 18 Sep 2020
        Replying to @sojunky @michaelmina_lab

        Not related to the graph, but "publication"... Back in May South Korea reported that issue about PCR test results and infectivity.https://www.cdc.go.kr/board/board.es?mid=a30402000000&bid=0030&act=view&list_no=367267&nPage=1 …

        0 replies 0 retweets 1 like
      3. End of conversation

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