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  1. proslijedio/la je Tweet
    20. stu 2019.

    This week on the Nature cover: Waves of mutation. Barcode system images evolutionary dynamics of laboratory yeast. Browse the issue here:

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  2. proslijedio/la je Tweet

    Over the next couple of days, I'll describe some of the essential components of our technology and how they make long term lineage tracking possible, including: A novel, hyper-directional, set of Lox sites Reiterative Cre-Lox cassette exchange The splicing trap

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    and I spent years tracking down rebellious cells that refused to acquire new barcodes. We analyzed how they managed to escape our selections and redesigned our system again and again to try to lead them in the right direction.

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    The same argument applies to cells that acquire the ability to circumvent selection during gene stacking. The minor flaws of technologies in synthetic biology seem to limit our ability to create complex combinations of simpler constructs.

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    In a traditional DNA barcoding applications, rare cells that acquire the ability to circumvent barcoding selection are not a big issue. In our case, these rebellious cells would be fatal, since they would have a huge advantage during the next round of barcode addition.

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    This fusion of these technologies allows us to sequentially add random DNA barcodes into an evolving population to create a time-sorted barcode array at a specific locus in each cell. Earlier barcodes on this array identify more distant ancestors.

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    Our technique is an attempt to recombine two existing technologies, high resolution DNA barcoding (see ), and gene stacking (e.g. ).

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    Here's a thread telling the story of our new technique for genetic recording of lineage history during long term evolution experiments. The work was co-led with and in 's lab. Read the paper here:

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  9. proslijedio/la je Tweet
    13. stu 2019.

    What does evolution look like? We developed a rebarcoding approach to observe the travelling wave of adaptation at extremely high resolution. See short summaries by co-authors , in the lab of . Read the paper here:

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  10. proslijedio/la je Tweet
    13. stu 2019.

    What do you expect evolution to look like in a microbial population? Check out our new study offering a view of that over 1000 generations in yeast in the lab. co-led by , , in 's lab

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  11. proslijedio/la je Tweet
    24. lis 2019.

    Our Tn-Seq paper with , Alena Martsul and is out in . Accompanied by a nice perspective by Craig Miller with a cool fitness landscape: Here is my original summary:

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  12. proslijedio/la je Tweet
    20. lip 2019.

    Our new preprint “Higher fitness yeast genotypes are less robust to deleterious mutations” is out. , an amazing PhD student in lab, led this collaborative work. Alena Martsul from my lab also contributed. Please provide feedback!

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  13. proslijedio/la je Tweet
    30. pro 2018.

    End-of-year rant: Soft sweeps (equivalent adaptations arising independently multiple times) are common in RNA viruses. Stirring up a debate on this non-issue using simplistic models and dubious parameters is a waste of time. More here:

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  14. 8. stu 2018.

    Work led by Dan Rice (and in collaboration w/) on signatures of non-Kingman coalescence

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  15. proslijedio/la je Tweet
    29. svi 2018.

    How does strong background selection influence the site frequency spectrum? Our paper published today online at explains. With and .

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    30. lis 2017.

    Our new preprint on the signatures of strong background selection is now available!

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  18. proslijedio/la je Tweet
    30. kol 2017.

    Some sequencing in challenging environment: theoretical physics institute

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  19. 24. tra 2016.

    Very sad to hear about Paul Joyce. He was a fantastic colleague, always great to talk to, I learned a lot from him and from his work

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