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Michael Desai proslijedio/la je Tweet
This week on the Nature cover: Waves of mutation. Barcode system images evolutionary dynamics of laboratory yeast. Browse the issue here: https://go.nature.com/336w2ip pic.twitter.com/pe16RxYmiG
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Michael Desai proslijedio/la je Tweet
Over the next couple of days, I'll describe some of the essential components of our technology and how they make long term lineage tracking possible, including: A novel, hyper-directional, set of Lox sites Reiterative Cre-Lox cassette exchange The splicing trap
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Michael Desai proslijedio/la je Tweet
@alex_nguyen_ba and I spent years tracking down rebellious cells that refused to acquire new barcodes. We analyzed how they managed to escape our selections and redesigned our system again and again to try to lead them in the right direction.Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Michael Desai proslijedio/la je Tweet
The same argument applies to cells that acquire the ability to circumvent selection during gene stacking. The minor flaws of technologies in synthetic biology seem to limit our ability to create complex combinations of simpler constructs.
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Michael Desai proslijedio/la je Tweet
In a traditional DNA barcoding applications, rare cells that acquire the ability to circumvent barcoding selection are not a big issue. In our case, these rebellious cells would be fatal, since they would have a huge advantage during the next round of barcode addition.
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Michael Desai proslijedio/la je Tweet
This fusion of these technologies allows us to sequentially add random DNA barcodes into an evolving population to create a time-sorted barcode array at a specific locus in each cell. Earlier barcodes on this array identify more distant ancestors.
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Michael Desai proslijedio/la je Tweet
Our technique is an attempt to recombine two existing technologies, high resolution DNA barcoding (see http://nature.com/articles/nature14279 …), and gene stacking (e.g. http://nature.com/articles/nbt.2825 …).
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Michael Desai proslijedio/la je Tweet
Here's a thread telling the story of our new technique for genetic recording of lineage history during long term evolution experiments. The work was co-led with
@alex_nguyen_ba and@ivana_cvijovic in@MichaelMDesai's lab. Read the paper here:http://nature.com/articles/s41586-019-1749-3 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Michael Desai proslijedio/la je Tweet
What does evolution look like? We developed a rebarcoding approach to observe the travelling wave of adaptation at extremely high resolution. See short summaries by co-authors
@ivana_cvijovic,@jireva in the lab of@MichaelMDesai. Read the paper here:https://www.nature.com/articles/s41586-019-1749-3 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Michael Desai proslijedio/la je Tweet
What do you expect evolution to look like in a microbial population? Check out our new study offering a view of that over 1000 generations in yeast in the lab. co-led by
@alex_nguyen_ba,@jireva, in@MichaelMDesai 's labhttps://www.nature.com/articles/s41586-019-1749-3 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Michael Desai proslijedio/la je Tweet
Our Tn-Seq paper with
@_miloj, Alena Martsul and@MichaelMDesai is out in@sciencemagazine. https://science.sciencemag.org/content/366/6464/490 … Accompanied by a nice perspective by Craig Miller with a cool fitness landscape: https://science.sciencemag.org/content/366/6464/418 … Here is my original summary: https://twitter.com/skryazhi/status/1141821852047704064?s=20 …pic.twitter.com/Lu00tyqYUR
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Michael Desai proslijedio/la je Tweet
Our new preprint “Higher fitness yeast genotypes are less robust to deleterious mutations” is out.
@_miloj, an amazing PhD student in@MichaelMDesai lab, led this collaborative work. Alena Martsul from my lab also contributed. Please provide feedback!https://www.biorxiv.org/content/10.1101/675314v1 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Michael Desai proslijedio/la je Tweet
End-of-year rant: Soft sweeps (equivalent adaptations arising independently multiple times) are common in RNA viruses. Stirring up a debate on this non-issue using simplistic models and dubious parameters is a waste of time. More here: https://neherlab.org/201812_softsweeps.html …pic.twitter.com/KzEEYjwkcI
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Work led by Dan Rice (and in collaboration w/
@jnovembre) on signatures of non-Kingman coalescencehttps://twitter.com/biorxivpreprint/status/1058913135145443335 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Michael Desai proslijedio/la je Tweet
How does strong background selection influence the site frequency spectrum? Our paper published today online at
@GeneticsGSA explains. With@benjaminhgood and@MichaelMDesai. http://www.genetics.org/content/early/2018/05/29/genetics.118.301058 …pic.twitter.com/IYjRJnXQ4o
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Michael Desai proslijedio/la je Tweet
Friday night music on Saturday: from a concert last nighthttps://www.nytimes.com/2018/03/31/opinion/friday-night-music-on-saturday-the-lone-bellow.html …
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Michael Desai proslijedio/la je Tweet
Our new preprint on the signatures of strong background selection is now available!
@benjaminhgood@MichaelMDesaihttps://twitter.com/biorxivpreprint/status/925105225320583169 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Michael Desai proslijedio/la je Tweet
Some
@nanopore sequencing in challenging environment: theoretical physics institute#KITPqbiopic.twitter.com/rZQxA6SmlE
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Very sad to hear about Paul Joyce. He was a fantastic colleague, always great to talk to, I learned a lot from him and from his work
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