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Reading Bill Gates, John Doerr and Andy Grove on OKRs: https://www.gatesnotes.com/Books/Measure-What-Matters?WT.mc_id=20180516172000_MeasureWhatMatters_BG-LI&WT.tsrc=BGLI&linkId=51788990 … It sounds like an interesting approach for many lines of work (e.g., engineering at Intel), but unsuitable for research.
Are there similarly effective frameworks for managing one's own (or helping others') research?
Why do you think OKRs aren't useful for research?
If you hit your objectives in research, it means things have gone badly.
Perhaps “You and Your Research” / “The Art of Doing Science and Engineering” (book/lectures) by Richard W. Hamming and “Advice for a Young Investigator” by Santiago Ramón y Cajal?
I've read both. Lots of useful advice, but neither is a periodic evaluative framework for assessing one's research.
From http://web.mit.edu/tslvr/www/lessons_two_years.html …. In my view, careful and deliberate documentation of your ideas / "experiments". "Failed" experiments may be the best (only?) indication we have for evaluating research progress. 
pic.twitter.com/g9fz6HmljQ
I doubt any top-down management approach can be useful for research, which is intrinsically bottom-up. So... are there effective frameworks for assessing bottom-up activities?
If you find any, please let me know!
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