You might find the second point under "Lessons learned" in this blog post useful https://www.openphilanthropy.org/blog/our-second-chance-program-nih-transformative-research-applicants …
The NIH's "high risk" grant programs: https://commonfund.nih.gov/highrisk Anyone know on what basis they call it high risk? Do they actually track failure rates? Or is it just signalling?
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It doesn't surprise me. Every sensible scientist knows "high risk" etc are cheap talk. If I had a nickel for every time I've heard a program officer talk about wanting to support "high risk" work, I wouldn't need grants.
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They lean more towards funding people not projects i.e. care about vision + require less preliminary data in a proposal + assess person based on early/mid/senior career status.
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My answer based on how colleagues and mentors navigate the proposal process and how reviewers evaluate proposal relative to R-series grants. Not sure how the outcomes are tracked officially.
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