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michael_nielsen's profile
michael_nielsen
michael_nielsen
michael_nielsen
@michael_nielsen

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michael_nielsen

@michael_nielsen

Searching for the numinous. Co-purveyor of https://quantum.country/ 

San Francisco, CA
michaelnielsen.org
Joined July 2008

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    1. Titus Brown‏ @ctitusbrown 10 Jan 2016
      • Report Tweet
      Replying to @ctitusbrown

      @michael_nielsen however, strain variation and polymorphism complicate matters, along with so-called "pan genomes".

      1 reply 0 retweets 1 like
    2. Titus Brown‏ @ctitusbrown 10 Jan 2016
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      Replying to @ctitusbrown

      @michael_nielsen I personally think a good operational definition is "do sequences from these two organisms assemble together" :)

      1 reply 0 retweets 2 likes
    3. Titus Brown‏ @ctitusbrown 10 Jan 2016
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      Replying to @ctitusbrown

      @michael_nielsen sort of a computational definition of sex. But I've never explored the idea.

      3 replies 0 retweets 2 likes
    4. Titus Brown‏ @ctitusbrown 10 Jan 2016
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      Replying to @ctitusbrown

      @michael_nielsen if you write something on it, I'm happy to publicize it and join in with everyone in telling you why it's wrong. :)

      2 replies 0 retweets 2 likes
    5. michael_nielsen‏ @michael_nielsen 10 Jan 2016
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      Replying to @ctitusbrown

      @ctitusbrown on known solutions, then use the model to (quickly!) do future "simulations". Apparently useful for doing real time 3d graphics

      1 reply 0 retweets 1 like
    6. Titus Brown‏ @ctitusbrown 10 Jan 2016
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      Replying to @michael_nielsen

      @michael_nielsen you're assuming we have a good objective function. I'm not sure we do :)

      2 replies 0 retweets 1 like
    7. michael_nielsen‏ @michael_nielsen 10 Jan 2016
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      Replying to @ctitusbrown

      @ctitusbrown So with my genome and a hippo genome the model would be trained to say "not the same species"

      1 reply 0 retweets 0 likes
    8. Titus Brown‏ @ctitusbrown 10 Jan 2016
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      Replying to @michael_nielsen

      @michael_nielsen sure, but in addition to epistemological confusion, I would worry about sampling bias in training set.

      2 replies 0 retweets 0 likes
    9. Titus Brown‏ @ctitusbrown 10 Jan 2016
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      Replying to @ctitusbrown

      @michael_nielsen also not entirely sure that the way we think about species is interesting. corner cases <=> sampling bias rel'n.

      1 reply 0 retweets 1 like
    10. Titus Brown‏ @ctitusbrown 10 Jan 2016
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      Replying to @ctitusbrown

      @michael_nielsen anyways, off to do some stuff with my two kids. laters!

      1 reply 0 retweets 1 like
      michael_nielsen‏ @michael_nielsen 10 Jan 2016
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      Replying to @ctitusbrown

      @ctitusbrown Have fun! Thanks for the convo!

      11:16 AM - 10 Jan 2016
      • 1 Like
      • Titus Brown
      1 reply 0 retweets 1 like
        1. Titus Brown‏ @ctitusbrown 10 Jan 2016
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          Replying to @michael_nielsen

          @michael_nielsen the ANI paper is a good read. Nice, straightforward, simple, not terribly wrong :)

          0 replies 0 retweets 1 like
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