Is there a good algorithm for determining whether two genomes come from the same or different species? (G Scholar doesn't imm show a'thing)
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Replying to @ctitusbrown
@michael_nielsen well, ok, not really. It boils down to def'n of species. In bacteria, see Kostas work: http://www.ncbi.nlm.nih.gov/pubmed/261504202 replies 2 retweets 3 likes -
Replying to @ctitusbrown
@michael_nielsen however, strain variation and polymorphism complicate matters, along with so-called "pan genomes".1 reply 0 retweets 1 like -
Replying to @ctitusbrown
@michael_nielsen I personally think a good operational definition is "do sequences from these two organisms assemble together" :)1 reply 0 retweets 2 likes -
Replying to @ctitusbrown
@michael_nielsen sort of a computational definition of sex. But I've never explored the idea.3 replies 0 retweets 2 likes -
Replying to @ctitusbrown
@michael_nielsen if you write something on it, I'm happy to publicize it and join in with everyone in telling you why it's wrong. :)2 replies 0 retweets 2 likes -
Replying to @ctitusbrown
@ctitusbrown on known solutions, then use the model to (quickly!) do future "simulations". Apparently useful for doing real time 3d graphics1 reply 0 retweets 1 like -
Replying to @michael_nielsen
@michael_nielsen you're assuming we have a good objective function. I'm not sure we do :)2 replies 0 retweets 1 like
@ctitusbrown I mean in instances where there is an acknowledged ground truth. I hope it's agreed that I am not a hippopotamus, for example.
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