But suppose an individual starts a grant agency or university in their proverbial garage. They simply can’t grow it to outcompete incumbents ("We're replacing the NIH!" “We’re replacing Harvard!”), even if their approach is vastly better.
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Finally, technology: What’s going to be the impact of AI on science? Of intelligence augmentation? Of ideas like open science? Might one or more of these dramatically speed up scientific progress?
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Of course, these are just a few ideas. I believe humanity has barely begun to explore the space of possible approaches to doing science. What are the high-order bits in how we do science? What new approaches can we take to discovery?
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We’re both very, very optimistic that we can do vastly better than today. But it needs new ideas, lots of experiments, and lots of imagination!
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End of conversation
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This is actually true for a few POs I know. Not necessarily job on the line but a strong talking to from the overlords.
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Curious - can you say who? (Maybe in DM.)
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In biology, 33k papers mention the protein p53 in the title - whilst the function of almost 20% of all human proteins are known unknowns https://www.biorxiv.org/content/early/2018/11/16/469569 … ...the roads not taken
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Agree completely. Per my previous response, this is why “science” is broken. From the top down, funding and tenure for scientists has zero tolerance for failure. But science has to be linked with failure. That’s why we see a million micro-successes and 0 big discoveries nowadays.
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