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michael_nielsen's profile
michael_nielsen
michael_nielsen
michael_nielsen
@michael_nielsen

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michael_nielsen

@michael_nielsen

Searching for the numinous. Co-purveyor of https://quantum.country/ 

San Francisco, CA
michaelnielsen.org
Joined July 2008

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    1. michael_nielsen‏ @michael_nielsen 16 Nov 2018
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      But suppose an individual starts a grant agency or university in their proverbial garage. They simply can’t grow it to outcompete incumbents ("We're replacing the NIH!" “We’re replacing Harvard!”), even if their approach is vastly better.

      3 replies 6 retweets 37 likes
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    2. michael_nielsen‏ @michael_nielsen 16 Nov 2018
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      That is: there is no strong growth model or notion of competitive displacement for scientific institutions. And this means stasis and homogeneity and monoculture, a lack of organizational change and learning. This is terrible for science.

      3 replies 37 retweets 149 likes
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    3. michael_nielsen‏ @michael_nielsen 16 Nov 2018
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      Indeed, it creates a sense that science _must_ be done this way. We must have PIs, a group is composed in such-and-such a way, scientists have a particular career path, are of a particular age, have a certain type of mentoring, produce a certain kind of output, etc.

      3 replies 9 retweets 72 likes
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    4. michael_nielsen‏ @michael_nielsen 16 Nov 2018
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      But we could change each (or every!) one of these in radical ways.

      1 reply 2 retweets 32 likes
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    5. michael_nielsen‏ @michael_nielsen 16 Nov 2018
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      Furthermore, it produces apathy. Every scientist has ideas for how to do things differently at the institutional level. But without a growth model for the best ideas, it's easy to feel it's not worth it, that things are forever stuck.

      2 replies 4 retweets 30 likes
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    6. michael_nielsen‏ @michael_nielsen 16 Nov 2018
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      If you start a better grant agency, it's not going to displace the NIH. But perhaps it should.

      4 replies 2 retweets 19 likes
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    7. michael_nielsen‏ @michael_nielsen 16 Nov 2018
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      A few ideas I like (no implied endorsement by Patrick, or originality on my part). Very telegraphic & incomplete - lots of nuance missing, and obvious problems that need to be addressed.

      2 replies 3 retweets 13 likes
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    8. michael_nielsen‏ @michael_nielsen 16 Nov 2018
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      Figure out how new fields are produced. At the moment there's a _lot_ of inhibitory forces that slow the rate of production of new fields. Can we programmatically 2x or 10x or 100x the rate of new field production?

      3 replies 11 retweets 59 likes
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    9. michael_nielsen‏ @michael_nielsen 16 Nov 2018
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      Far more varied funding strategies: eg by golden ticket (where 1 reviewer can ok a project, https://www.nature.com/articles/d41586-018-02743-2 … ); by variance in reviewer scores, using high variance (loved by some, hated by others) as a positive signal; or randomized allocationhttps://mbio.asm.org/content/7/2/e00422-16 …

      1 reply 9 retweets 48 likes
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    10. michael_nielsen‏ @michael_nielsen 16 Nov 2018
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      Tenure insurance. For a relatively small additional piece of the benefits package, tenure-track faculty are guaranteed a large payout should they fail to get tenure. It's a cheap way to de-risk the tenure process, and to encourage more risk-taking.

      3 replies 8 retweets 47 likes
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      michael_nielsen‏ @michael_nielsen 16 Nov 2018
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      Almost every funder talks about supporting high-risk research. But that is often just talk. A genuinely high-risk program would evaluate failure rates for past grants, and if the failure rate was _too low_ (below 60%, say), the program officer's job would be on the line.

      5:38 AM - 16 Nov 2018
      • 20 Retweets
      • 79 Likes
      • Rahul Ramchandani Marcus Denker Nick Baum 🇸🇪 Tim Triche, Jr. Amit Sinha Alexander Piper John Carlos Baez Fred Ehrsam Felix Leung
      4 replies 20 retweets 79 likes
        1. New conversation
        2. michael_nielsen‏ @michael_nielsen 16 Nov 2018
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          Finally, technology: What’s going to be the impact of AI on science? Of intelligence augmentation? Of ideas like open science? Might one or more of these dramatically speed up scientific progress?

          4 replies 2 retweets 27 likes
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        3. michael_nielsen‏ @michael_nielsen 16 Nov 2018
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          Of course, these are just a few ideas. I believe humanity has barely begun to explore the space of possible approaches to doing science. What are the high-order bits in how we do science? What new approaches can we take to discovery?

          1 reply 3 retweets 30 likes
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        4. michael_nielsen‏ @michael_nielsen 16 Nov 2018
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          We’re both very, very optimistic that we can do vastly better than today. But it needs new ideas, lots of experiments, and lots of imagination!

          15 replies 2 retweets 43 likes
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        5. End of conversation
        1. New conversation
        2. Karthik Ram‏ @_inundata 16 Nov 2018
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          Replying to @michael_nielsen

          This is actually true for a few POs I know. Not necessarily job on the line but a strong talking to from the overlords.

          1 reply 0 retweets 1 like
        3. michael_nielsen‏ @michael_nielsen 16 Nov 2018
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          Replying to @_inundata

          Curious - can you say who? (Maybe in DM.)

          0 replies 0 retweets 0 likes
        4. End of conversation
        1. Antonia Lock‏ @Antonia_Nilsson 16 Nov 2018
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          Replying to @michael_nielsen

          In biology, 33k papers mention the protein p53 in the title - whilst the function of almost 20% of all human proteins are known unknowns https://www.biorxiv.org/content/early/2018/11/16/469569 … ...the roads not taken

          0 replies 2 retweets 12 likes
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        1. Charles B Sweeney‏ @sweenzorrr 18 Nov 2018
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          Replying to @michael_nielsen @MicahJGreen

          Agree completely. Per my previous response, this is why “science” is broken. From the top down, funding and tenure for scientists has zero tolerance for failure. But science has to be linked with failure. That’s why we see a million micro-successes and 0 big discoveries nowadays.

          0 replies 0 retweets 0 likes
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