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mesolude's profile
Marie La
Marie La
Marie La
@mesolude

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Marie La

@mesolude

Like warm butter on the toast of despair 🌱the opposite of judgment is curiosity || rationalist, dungeon master, writer

San Francisco, CA
narrativemancy.com
Joined January 2013

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    1. Marie La‏ @mesolude Jan 12
      • Report Tweet

      Discussion about placebos often focuses on the boring thing: "gotcha, the treatment didn't work the way you thought it would.." The cool thing about placebos is past that: "..didn't work the way you thought it would, because the body did ??something?? and fixed itself"

      3 replies 2 retweets 31 likes
      Show this thread
      Marie La‏ @mesolude Jan 12
      • Report Tweet

      I badly want to understand what that 'something' is that a colored pill or an entire surgery might trigger

      12:10 PM - 12 Jan 2020
      • 1 Retweet
      • 13 Likes
      • Aryeh 𐡎𐡀𐡒‘ 𐡀 𐡅𐡀𐡍 Allison Bojarski William Eden QC Maxim Leyzerovich Peter Borah Jonathan Wallis Ian Hines
      9 replies 1 retweet 13 likes
        1. Marie La‏ @mesolude Jan 13
          • Report Tweet

          .@adamjensenat brought up nocebos, placebos' negative opposite. And that we might be experiencing nocebo effects /right now/, which could be some sweet sweet low hanging fruit if so

          1 reply 1 retweet 3 likes
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        2. Matt Canute‏ @Matt_Canute Jan 12
          • Report Tweet
          Replying to @mesolude

          I've read somewhere that when your body is relaxed during a car crash, rather than tensed up, that can reduce chances of a bad injury. Similarly, I'd expect that part of the placebo effect is from relaxing due to worrying about it less, because "oh the pill will take care of it!"

          1 reply 0 retweets 0 likes
        3. Marie La‏ @mesolude Jan 12
          • Report Tweet
          Replying to @Matt_Canute

          I haven't considered that! Stress is a major contributor to health problems, that does make sense

          0 replies 0 retweets 1 like
        4. End of conversation
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        2. Joscha Bach‏ @Plinz Jan 12
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          Replying to @mesolude

          Attention

          1 reply 0 retweets 2 likes
        3. Marie La‏ @mesolude Jan 12
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          Replying to @Plinz

          What kind of attention works best? Why would this work? (Not that I disagree, but 'attention' is vague)

          1 reply 0 retweets 0 likes
        4. 1 more reply
        1. New conversation
        2. Nick Cammarata‏ @nicklovescode Jan 12
          • Report Tweet
          Replying to @mesolude

          It also sets a (shockingly powerful) lower bound to what is possible just by thinking I wouldn’t be surprised if the right kind of not yet invented meditation can capture at least this much upside

          2 replies 0 retweets 3 likes
        3. Nick Cammarata‏ @nicklovescode Jan 12
          • Report Tweet
          Replying to @nicklovescode @mesolude

          Prediction: once we have decent real time probes for things like GABA activity, people will be able to learn to gradient ascent it by learning a new sense Similar to learning to push/pull fake object with eeg, learning GAN latent space, see with tongue probes etc We’re v plastic

          1 reply 0 retweets 2 likes
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        2. James Babcock‏ @jimrandomh Jan 12
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          Replying to @mesolude

          I think placebo groups improve mostly for disappointing reasons: Regression to the mean, research fraud, and biased answers on the symptom survey. The main benefit of placebo-ideology is that a well-defined intervention is much harder to cheat on than an observational study.

          1 reply 0 retweets 1 like
        3. William Eden‏ @WilliamAEden Jan 12
          • Report Tweet
          Replying to @jimrandomh @mesolude

          But you can also ascertain the placebo effect when studies run a placebo *and* a no-treatment arm, and the placebo effect does still exist (albeit in a smaller slice of conditions)

          0 replies 0 retweets 2 likes
        4. End of conversation
        1. New conversation
        2. Luca Dellanna‏ @DellAnnaLuca Jan 12
          • Report Tweet
          Replying to @mesolude @StephenPiment

          Here I wrote about *some* of the ways in which placebos work http://luca-dellanna.com/pain-signal-vulnerability … TL;DR: Placebos act in 3+ ways: 1) sometimes, our body doesn’t deploy healing processes to save energy if he believes he might need it. Placebos signal safe environment → can heal [1/N]

          1 reply 0 retweets 1 like
        3. Luca Dellanna‏ @DellAnnaLuca Jan 12
          • Report Tweet
          Replying to @DellAnnaLuca @mesolude @StephenPiment

          2/ Pain is a signal of vulnerability, not of damage (though in lot of cases, damage is a predictor of vulnerability): it signals the need for a behavioral adjustment. If a placebo manages to make us subjectively feel less vulnerable, it will suppress pain. [2/N]

          1 reply 0 retweets 1 like
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