So here's a thing that happens to me: I pass out on trans-Atlantic flights. Like straight-up eyes-fluttering bonk, then I'm largely fine. I've never known anyone else this happens to, but I know it's A Thing that happens to people.
only going eastward, only over the atlantic. I think it has to do with altitude and how far into the flight we reach that altitude, and possibly when i've last eaten but i'm not 100% sure.