Iain Mathieson

@mathiesoniain

Population genetics, ancient DNA, statistics.

Philadelphia, PA
med.upenn.edu/mathieson-lab/
Joined April 2012
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  1. Pinned Tweet
    15 May 2017

    I'm recruiting postdocs. Come and work with me in sunny Philadelphia! Please RT!

    4 replies 144 retweets 69 likes
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  2. Retweeted
    Oct 11

    Dear geneticist friends who will perhaps go to the meeting in San Diego next week: I am giving a talk at the session called "Session #91: Biases of Polygenic Risk Scores" on Saturday, October 20th! Hope to perhaps see some of you there?!

    1 reply 7 retweets 11 likes
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  3. Oct 5

    Estimating Neanderthal ancestry proportions from 23andMe data:

    1 reply 21 retweets 45 likes
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  4. Sep 3

    I do not envy the person who had to enter all those names in the biorxiv submission system!

    The genetic architecture of the human cerebral cortex
    2 replies 26 likes
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  5. Aug 9

    Excellent review of an excellent book

    Some thoughts after reading “Bad Blood: Secrets and Lies in a Silicon Valley Startup”
    2 likes
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  6. Jul 26

    Seems pretty current to me!

    I only just downloaded about a month ago, which is to say that I don't think I've ever had a "current opinion" about anything. But in any case, I wrote this review about coalescent HMMs and demographic inference:
    Show this thread
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  7. Jul 23

    Is this a confusing way of saying the PCs of the genotypes, or is it some other thing?

    3 replies 4 likes
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  8. Jun 22

    Keep your friends close, but your reviewers closer.

    Replying to @pnatarajanmd
    I never recommend reviewers. Be wary of who you think are your ‘friends’/‘friendly reviewers’
    16 likes
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  9. May 21

    No joke. D statistics are all computed by hand in the Reich lab. Postdocs spend most of their time rolling dice to get jackknife confidence intervals.

    A friend had mentioned for years he once did "genetics simulations by hand" but could not remember any more detail. He finally found his notes on Coalescent Theory as taught by David Reich.
    4 replies 15 retweets 98 likes
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  10. May 21

    Extremely surprising. Must-read if you care about mutation rates.

    We find that the ratio of paternal to maternal mutations is already ~3:1 by puberty and remains stable with increasing parental ages => spermatogenesis does not underlie the male bias in human mutation 2/4
    Show this thread
    3 replies 8 retweets 27 likes
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  11. May 2

    Interesting paper on leprosy and leprosy resistance alleles in Medieval Denmark: Note that the rs3135388 T allele was introduced to Europe by Bronze Age Steppe migrations. Did they bring leprosy as well as plague?

    3 replies 21 retweets 54 likes
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  12. Retweeted
    Apr 15

    I am recruiting grad students and postdocs to join my lab in sunny California. Come, join the amazing popgen and evolution community at UC Berkeley! For details, see: . Please RT!

    1 reply 251 retweets 214 likes
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  13. Mar 8

    Massive

    Our new preprint on ancient genomes from southeast Asia. Kudos to , Lasse Vinner and for putting so much work into this project!
    8 likes
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  14. Retweeted
    Mar 5

    Postdoc and Research Assistant Professor Positions available in human population genomics at UPenn. Looking for creative and talented scientists to work on large integrative genomics projects. Please RT!

    105 retweets 60 likes
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  15. Feb 22

    Did not expect that. The most surprising ancient DNA paper of the week!

    Przewalski’s horses are feral descendants of Botai horses! Ancient DNA upends the horse family tree Ancient genomes revisit the ancestry of domestic and Przewalski’s horses
    2 retweets 25 likes
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  16. Feb 21

    ADMIXTURE clusters are not ancestral populations

    3 replies 7 retweets 43 likes
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  17. Feb 20

    Oh, this looks cool!

    Our new preprint on the Barbarian Migrations is now out on — Understanding 6th-Century Barbarian Social Organization and Migration through Paleogenomics —
    Show this thread
    2 retweets 10 likes
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  18. Feb 19

    Being promoted up to steering a chariot that has no wheels. And if you can't convince the emperor to give you a grant, you get fed to the lions.

    Being a new PI is like going from being one of the best racing horses at the Roman coliseum then suddenly being promoted up to steering the chariot.
    1 retweet 28 likes
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  19. Retweeted
    Feb 19

    Our framework for localizing adaptive sweeps, SWIF(r), is out today in Nature Communcations! Led by amazing postdoc Lauren Alpert Sugden, SWIF(r) reports per-site calibrated sweep probabilities.

    1 reply 50 retweets 80 likes
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  20. Feb 16

    If I wanted to do a PhD in ancient DNA, this is where I would go!

    Dept of Archaeogenetics at the is offering up to 10 fully-funded PhD positions beginning June 2018! Projects would focus on relationships between humans and pathogens, microbial evolution, and population expansions. Apply by 15 March 2018!
    1 reply 12 retweets 21 likes
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  21. Feb 2

    Non-overlapping magisteria

    Not something I expected to read in AJHG
    4 likes
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