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marcan42's profile
Hector Martin
Hector Martin
Hector Martin
@marcan42

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Hector Martin

@marcan42

If it ain't broke, I'll fix it! I'm porting Linux to Apple Silicon Macs at @AsahiLinux. http://patreon.com/marcan  | http://github.com/sponsors/marcan 

Tokyo, Japan
marcan.st
Joined May 2009

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    1. carb0nyle  🦠 🧬 ☣️‏ @carb0nyle 10 Jun 2018
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      Replying to @marcan42

      https://what-if.xkcd.com/31/ 

      1 reply 0 retweets 1 like
    2. Hector Martin‏ @marcan42 10 Jun 2018
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      Replying to @carb0nyle

      Yes, that's what I was reminded of. I just re-ran the numbers with current microSD card densities.

      1 reply 0 retweets 0 likes
    3. Richard‏ @benjymous 10 Jun 2018
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      Replying to @marcan42 @carb0nyle

      I'm wondering now what the storage density of DNA is.

      1 reply 0 retweets 0 likes
    4. Richard‏ @benjymous 10 Jun 2018
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      Replying to @benjymous @marcan42 @carb0nyle

      215 petabytes per gram, apparently https://en.m.wikipedia.org/wiki/DNA_digital_data_storage … Crap, someone let the swarm of the internet out again.

      1 reply 0 retweets 1 like
    5. carb0nyle  🦠 🧬 ☣️‏ @carb0nyle 11 Jun 2018
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      Replying to @benjymous @marcan42

      The concept of storing information in DNA is indeed very tempting. The calculation might be correct, however this assumes a single copy of the information. PCR is extremely sensitive but It would be risky to keep only one copy as DNA tend to degrade / hydrolyse

      1 reply 0 retweets 0 likes
    6. carb0nyle  🦠 🧬 ☣️‏ @carb0nyle 11 Jun 2018
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      Replying to @carb0nyle @benjymous

      and even if sequencing cost decreased by order of magnitude (and continue to) is still to expensive for storage (and synthesis is also expensive) but it's still a promising field

      1 reply 0 retweets 0 likes
    7. Hector Martin‏ @marcan42 11 Jun 2018
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      Replying to @carb0nyle @benjymous

      The "single copy" issue is irrelevant. These are all order-of-magnitude estimates anyway. As long as your degradation rate isn't abysmal (e.g. >50% of your data goes away), the overhead of using an appropriate error detection and erasure coding scheme is well below error margins.

      3 replies 0 retweets 0 likes
    8. carb0nyle  🦠 🧬 ☣️‏ @carb0nyle 11 Jun 2018
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      Replying to @marcan42 @benjymous

      It's a very exciting topic and if you know about good papers treating about error correction for DNA storage I'll be interested to read them

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    9. Hector Martin‏ @marcan42 11 Jun 2018
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      Replying to @carb0nyle @benjymous

      I don't know anything specific to DNA, but in general look up things like Reed-Solomon and Shingled Erasure Codes. These techniques are fairly agnostic to the actual underlying storage mechanism. They're used in everything from CDs to cluster storage to satellite comms.

      1 reply 0 retweets 1 like
    10. Hector Martin‏ @marcan42 11 Jun 2018
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      Replying to @marcan42 @carb0nyle @benjymous

      This kind of approach is unlikely to evolve in nature, because it's basically complex mathematics, but it's trivial to do once you put a computer in front of the storage. So you don't have to worry too much about the specifities of DNA storage.

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      Hector Martin‏ @marcan42 11 Jun 2018
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      Replying to @marcan42 @carb0nyle @benjymous

      The same goes for bias. Transmission and storage mechanisms already have this problem, and the solution is whitening, which is basically scrambling the data to be statistically uniform, thus avoiding any excess incidence of biased sequences.

      3:15 AM - 11 Jun 2018
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        1. DrTune‏ @drtune 11 Jun 2018
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          Replying to @marcan42 @carb0nyle @benjymous

          Yeah people have got really good at wringing performance out of systems (especially magnetic and electron storage & radio) pushing them to the point where they barely work any more, and then fixing everything with, say BCH or LDPC coding. Magical sprinkles.

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