Idle thought: ~30 shipping containers full of 512GB microSD cards could store all of the world's data.https://twitter.com/marcan42/status/1005721534533550081?s=19 …
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and even if sequencing cost decreased by order of magnitude (and continue to) is still to expensive for storage (and synthesis is also expensive) but it's still a promising field
The "single copy" issue is irrelevant. These are all order-of-magnitude estimates anyway. As long as your degradation rate isn't abysmal (e.g. >50% of your data goes away), the overhead of using an appropriate error detection and erasure coding scheme is well below error margins.
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I disagree about this issue to be irrelevant, but I agree on the necessities of error correction / checksum. Working with DNA can be tricky, eg some sequences preferably amplified, this introduce biais. I would prefer to have redundancy in the information
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But you're perfectly right in the sense that Nature has chosen to keep a single copy (in haploid organisms) and the cell has many ways to detect error during replication, correct mutation, ensure genome integrity, so it demonstrates is possible.
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It's a very exciting topic and if you know about good papers treating about error correction for DNA storage I'll be interested to read them
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I don't know anything specific to DNA, but in general look up things like Reed-Solomon and Shingled Erasure Codes. These techniques are fairly agnostic to the actual underlying storage mechanism. They're used in everything from CDs to cluster storage to satellite comms.
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