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To arb spot effectively you ideally want to get filled passively on one of the legs, so you collect spread and pay a reduced fee. You then cross spread to hedge on the other exchange. But getting filled passively requires volume!
Volume helps in two regards - first it creates opportunities (e.g. a big trade on one exchange pushes up the price there) and second it gives better passive entry opportunities. Lower volume means less profit for arbs.
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