This is a good question! Some possible answers - 1. Infrastructure that is too expensive or too hard to build yourself (eg colocation, low latency data feeds, compute clusters, fpgas) 2. Data that is too expensive or simply impossible to buy (eg historical tick data)https://twitter.com/mobile_mm/status/1373427747901542402 …
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I often hear Citadel referred to as a quant fund which is not strictly accurate (lots of discretionary traders) but not completely inaccurate (lots of quant all over the place, eg to hedge factors in their long/short book or in the central risk book).
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Funds like Brevan and Rokos have big quant teams even though the main strategy is clearly not quant (got to build those curves and price those derivatives) and I hear they are looking more at systematic nowadays.
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