This is pretty incredible. Vaccine makers suggesting the change in U.K. policy on vaccine dose sequencing is potentially hugely flawed. Are we snatching defeat out of the jaws of victory?https://twitter.com/BenKentish/status/1344584306589638656 …
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All of the difference between 1 dose and 2 dose regime happens in the first ten days after the first dose, when there is no immunity. You would have this period whether you are in a 1 dose or two dose regime.
In fact based on Pfizer’s own data, there is no evidence that the second dose does anything at all! All we can say is that two doses is effective. They didn’t test one dose regime so hard to say, but there’s some evidence (and our priors) that one dose is pretty good.
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