What do you think happens to a population with an effective population size of 30 to 100 undergoing selection for decades?
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genetic variation is generated faster than you can select on a lot of the time (not sure if I should say most)
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The answer, it seems to me, is to engineer a breeding program whereby the mutation rate of the genome itself is negatively selected for. All resulting mutations in traits will conversely evolve within non genomic media.
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