I read the claim recently that compounds used recreationally are unusually likely to have therapeutic effects compared to random chemical
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it seems uncontroversial but I can’t find the source or any attempt at quantifying - anyone remember what I’m talking about?
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they’re including drugs used by human communities throughout the world including psychedelics not just what we’d call “recreational”
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I’m never gonna find it again huh
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omg
@TristanSevers found it http://slatestarcodex.com/2017/06/05/is-pharma-research-worse-than-chance/ …pic.twitter.com/9BaDOeQTyz
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Replying to @literalbanana @TristanSevers
this is also related to the thing where pharmaceutical companies want to get similar actions as Illegal Drug Molecules whilst not using the exact same molecules so they have to tinker and end up getting something shitty and not as effective and sometimes the clinical trials kill.
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Replying to @alt_kia @literalbanana
"The same thing but not addictive" (i.e. with orders of magnitude worse side effects)
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Replying to @TristanSevers @literalbanana
so you want to make an agent that fusses with the endocannabinoid system but instead of taking the simple and robustly tested path (cannabis-derived compounds) they tried to make an inhibitor of an enzyme that breaks down endocannabinoid compounds and it unfortunately made it to
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clinical trial, with nightmarish adverse effects for the people who didnt die outright https://en.wikipedia.org/wiki/BIA_10-2474#Death_and_serious_adverse_events …
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