CONGRESS |#ASH22 Shawn Lee, highlights results from the drug sensitivity analysis of pediatric ALL subtypes, and its effect on in vivo treatment responses. Pharmacotypes varied widely across subtypes and strongly impacted treatment response and survival outcomes
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Munich Leukemia Laboratory’s Tweets
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Enjoyed talking about #AI and regulatory challenges in the #ASH2022 session on AI/ML in hematology but I loved the fantastic questions & discussion with the @ASH_hematology audience. Great talks by fellow speakers @AzizNazhaMD Manja Meggendorfer & @IlanaGGoldberg #ASH22
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Dr. Meggendorfer talks about the interplay of #TP53 allelic state, blast count, and karyotype on survival of patients with #AML and #MDS at #ASH22 #CancerGenetics
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CONGRESS | #ASH22 Constance Baer, discusses a validation of IPSS-M and comparison to Nazha et al. and Bersanelli et al. models. The increased predictive power of IPSS-M over IPSS-R was confirmed. The new scoring systems had varying abilities to predict outcomes.
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Very nice talk by Thomas Beder from at #ASH22 presenting their new model ALLCatchR (github.com/ThomasBeder/AL) to reliable classify BCP-ALL samples based on gene expression profiles #WTS #CancerTranscriptomics
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📄Analysis of 704 (#WGS data) & 1804 (targeted sequencing) de novo #MDS demonstrated the negative prognostic impact of #RUNX1mut in #SF3B1mut pat➡️suggestion to exclude RUNX1mut from MDS-SF3B1 entity #NGS #CancerGenomics pubmed.ncbi.nlm.nih.gov/36463343/
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📄A retrospective analysis of 43 adult patients with TP53-mutated #ALL shows that a substantial number of patients harbor somatic TP53mut in a pre-leukemic compartment that is capable of self-renewal and clonal expansion and persists during remission pubmed.ncbi.nlm.nih.gov/36450137/
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1/n Single-cell data analysis is complex with many tools to choose from - but which ones work best and should be used when? Led by and , we wrote a free online book that aims to guide single-cell data analysts: sc-best-practices.org
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📄Analysis of 131 T-ALL showed that #CBA, supplemented by FISH & RT-PCR, allows to classify 46% of T-#ALL into different genetically defined entities. #WGS data can be used to classify an additional 17% and unclassified cases might be clarified by #WTS rdcu.be/cY1dm
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📄90 hospitalized COVID-19 patients were analyzed for #CHIP. 37.8% of the pts carried a CHIP-driver mutation (expected prevalence: 17%)➡️CHIP is a risk factor for COVID-19 courses requiring hospitalization. But CHIP had no age-independent impact on outcome bit.ly/3h7UcWx
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Looking to advance your #hematology research with #nextgenerationsequencing? Join us for our webinar, “The Future of Personalized Genomics,” to learn about the pivotal role #NGS plays in genetic profiling and personalized medicine: idtb.io/39tlir
@leukaemielabor
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📄DNA methylation profiling reveals PSMD5 hypermethylation as a novel mechanism of Proteasome inhibitor tolerance in #MultipleMyeloma. NDMM patients + PBMCs & CD138+ plasma cells from healthy donors generally show unmethylated profiles pubmed.ncbi.nlm.nih.gov/36282272/ #CancerGenomics
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📄MDS with #SF3B1mut & blast count <5% was proposed as a distinct entity (SF3B1ent) with favorable prognosis. Evaluation of 144 SF3B1ent #MDS cases identified del(5q) and RUNX1mut as negative prognostic factors for OS, while blast count >5% was not. #WGS
rdcu.be/cXS5I
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The future of diagnosis & treatment of #HematologicNeoplasms will inevitably involve the integration of #AI-based systems into routine practice to support the hematologists’ decision making. Unified concepts, transparent models & clear #SciComm will be key to general adoption👏
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Last week we founded the #AI working group in the German Society of #Hematology and #Oncology @dgho_eV. Very happy to be part of this, together with Dr. Rösler from @Unispital_USZ & many others dgho.de/arbeitskreise/ @XgegenKrebs @NCT_HD @DKFZ @DKTK_ @NCT_UCC_DD
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📄Our new review provides a comprehensive overview of implemented #MachineLearning techniques in diagnostic subspecialties of #hematology and the limitations & unresolved challenges of these systems doi.org/10.1016/j.blre #ArtificialIntelligence #PrecisionMedicine #Diagnostics
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📄169 #CLL samples were analyzed for cytogenetic clonal evolution (CCE) and #clonalEvolution affecting #TP53 & #SF3B1. The most frequently gained chrom aberration during CCE was TP53del, which was associated with SF3B1mut & an unmutated IGHV status pubmed.ncbi.nlm.nih.gov/36169893/
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Fascinating talk by Janne Lehtiö on #proteogenomics in cancer at #PrecisionMedicineEurope2022. Very interesting data on trisomy 12 CLL subgroups
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Thank you so much Stockholm for hosting us and thanks to Malte Kuhnemund and James Chell for providing us with an overview about the research and development processes - very impressive! #Visium #Xenium #SingleCell
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What is still needed to bring #LiquidBiopsy into clinical practice? Great talk by Catherine Alix-Panabières from at #PrecisionMedicineEurope2022
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Brilliant talk by from at #PrecisionMedicineEurope2022 about genetic #predisposition to #cancer - only mother nature knows the truth about whether a variant is pathogenic or benign, and we as humans can only try to infer this truth as best as we can
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Important point by Katrin Crameri of - everyone wants to work with real-world clinical data, but no one is willing to pay for the standardization & structuring of data that is the basic requirement for sharing data in a meaningful way #PrecisionMedicineEurope2022
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📢Published today in Genomic Profiling for Clinical Decision Making in Myeloid Neoplasms and Acute Leukemia | Blood | American Society of Hematology #hemepath #leusm #mdssm #mpnsm ashpublications.org/blood/article/
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Fascinating presentation by Dame Sue Hill at #PrecisionMedicineEurope2022 on the widespread implementation of genetic testing across the NHS, including #WGS for various diseases, and the importance of providing easy access to genetic testing to improve patient care
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There is limited data on the efficacy of treatments for the precursor disease #CCUS. An important step is the inclusion of CCUS as a separate entity in the #WHOHEME classification guidelines, which now allows comparison between different studies #MDS #cytopenia
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Fascinating talk by Ashley Sanders () on #SingleCell analysis of #StructuralVariations and complex rearrangements with tri-channel processing and functional characterization of detected patient subclones doi.org/10.1038/s41587 #SCGmeetsML
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Copy number variations are common in various hematologic malignancies but knowledge at the single cell level and patient heterogeneity is limited - nice talk by giving insights into #CNV calling from #scDNA and in particular #scATAC-seq #SCGmeetML
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Very interesting presentation by Christoph Bock () on time series analysis of response of #CLL patients to #ibrutinib treatment and different single-cell applications with the goal to "delay disease progression until the patient dies for unrelated reasons" #SCGmeetML
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Our Erasmus Virtual Hematology Lectures will continue on September 19 at 16.00 CET (every two weeks) with a fantastic line up.
us06web.zoom.us/j/89635130792
ID: 896 3513 0792
We will start with Omar Abdel Wahab from MSKCC.
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Last chance to submit an abstract...you really don't want to miss this scientific workshop at #ASH2022
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The current #classification of blood cancer is changing...at #ASH2022 there will be a workshop on the central role of genomics in reclassification and a discussion of emerging entities. Abstract submission deadline is Sept 5th: bit.ly/3CE1OZr
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Great keynote lecture and glad she lived up to her reputation and went over time
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We are off to a great start of the last day of the #Spetses2022 summer school with the awaited keynote lecture of Edith Heard @embl on X-chromosome inactivation!
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On to one of the last sessions at #spetses2022 - looking forward to the short talks by the students who have been selected to present their work. Congrats to our student Maki Sakuma for being part of this eclectic group #MDS #VEXAS #UBA1
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We are off to a great start for the Spetses Summer School and if the location doesn't inspire the students to do great scientific work in the future I don't know which would #spetses2022 #CancerEpigenetics
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The current #classification of blood cancer is changing...at #ASH2022 there will be a workshop on the central role of genomics in reclassification and a discussion of emerging entities. Abstract submission deadline is Sept 5th: bit.ly/3CE1OZr
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Digitization is an important step forward in keeping abreast of research advances and providing world-class guidelines to improve patient care #WHO #TumorClassification #Hematology
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the wait is finally over, the beta version of the 5th Ed. of the #WHO classification for haematolymphoid tumours (UK spelling 
) is finally online!!! Outstanding images and WSI… ENJOY 
#hemepath tumourclassification.iarc.who.int @JoeKhouryMD @IanCreeUK @AndreasHochhaus
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