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lee_jjj's profile
Lee
Lee
Lee
@lee_jjj

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Lee

@lee_jjj

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London, England
Joined July 2020

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    1. Edward Nirenberg‏ @ENirenberg 16 Oct 2020

      There are additionally multiple animal models that recapitulate (to varying degrees) disease: https://science.sciencemag.org/content/sci/368/6494/942.full.pdf … https://www.nature.com/articles/s41385-020-00340-z.pdf … https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250783/pdf/main.pdf … https://www.pnas.org/content/pnas/117/28/16587.full.pdf … https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401025/pdf/JEM_20201241.pdf … https://www.nature.com/articles/s41586-020-2324-7 …https://science.sciencemag.org/content/369/6505/812 …

      1 reply 3 retweets 36 likes
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    2. Edward Nirenberg‏ @ENirenberg 16 Oct 2020

      And phylogenies can be constructed of isolates: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366979/pdf/main.pdf … https://www.pnas.org/content/pnas/117/17/9241.full.pdf … https://nextstrain.org/sars-cov-2/  And I offer this one for some good news: https://www.pnas.org/content/pnas/117/38/23652.full.pdf …

      1 reply 2 retweets 33 likes
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    3. Edward Nirenberg‏ @ENirenberg 16 Oct 2020

      Its origin is unambiguously natural based on the best evidence available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095063/pdf/41591_2020_Article_820.pdf … https://www.nature.com/articles/s41586-020-2313-x … https://www.nature.com/articles/s41594-020-0468-7 … https://www.cell.com/action/showPdf?pii=S0092-8674%2820%2930328-7 … https://www.cell.com/cell/pdf/S0092-8674(20)31012-6.pdf …pic.twitter.com/5SEtrHF4Hf

      https://elifesciences.org/articles/57309
      2 replies 7 retweets 50 likes
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    4. Edward Nirenberg‏ @ENirenberg 16 Oct 2020

      Some denialists have proposed that SARS-CoV-2 is no virus at all, rather it is an exosome. Exosomes are extracellular vesicles made by cells to communicate with other cells. In principle, they resemble enveloped viruses. Except exosomes are not infectious.pic.twitter.com/9mQXarvAi3

      https://www.pnas.org/content/pnas/113/33/9155.full.pdf
      1 reply 1 retweet 44 likes
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    5. Edward Nirenberg‏ @ENirenberg 16 Oct 2020

      The fact that inoculation of susceptible and permissive cell cultures with SARS-CoV-2 produces cytopathic effects (CPE) and the virus can be isolated and this can be repeated ad infinitum plainly refutes this (the CPE can be viewed in some links above).

      1 reply 2 retweets 42 likes
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    6. Edward Nirenberg‏ @ENirenberg 16 Oct 2020

      Additionally, SARS-CoV-2 has been sequenced repeatedly. Its genome exhibits prototypical features common to coronaviruses and does not align with sequences present in our own genome, ruling out an endogenous origin.pic.twitter.com/pjmI2Ojsro

      https://www.jbc.org/content/early/2020/07/13/jbc.REV120.013930.full.pdf
      2 replies 2 retweets 45 likes
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    7. Edward Nirenberg‏ @ENirenberg 16 Oct 2020

      Some denialists also claim that SARS-CoV-2 is not the cause of COVID-19 because something something Koch's postulates (I have not heard a coherent statement of the canard so this is the best I can do in summarizing it).

      3 replies 2 retweets 33 likes
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    8. Edward Nirenberg‏ @ENirenberg 16 Oct 2020

      Koch's postulates 4 conditions that can be used to determine which pathogen (and whether a pathogen) is responsible for a given disease. However, as is eloquently explained here (https://www.virology.ws/2010/01/22/kochs-postulates-in-the-21st-century/ …) these conditions are imperfect and not readily applicable to viruses.

      1 reply 4 retweets 40 likes
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    9. Edward Nirenberg‏ @ENirenberg 16 Oct 2020

      Nonetheless, the fact that COVID-19 occurs in patients who are infected with SARS-CoV-2 and does not occur in those not infected by it is about as iron-clad evidence as any that SARS-CoV-2 is the cause of COVID-19.

      2 replies 6 retweets 53 likes
      Show this thread
    10. Edward Nirenberg‏ @ENirenberg 16 Oct 2020

      I am begging you- stop contributing to the misinfodemic we have at play. It is killing people. Fact check claims put before you. Listen to experts. Wear your mask. Physically distance. Wash your hands.

      13 replies 22 retweets 139 likes
      Show this thread
      Lee‏ @lee_jjj 24 Oct 2020
      Replying to @ENirenberg

      ‘Misinfodemic’! I think you mean healthy debate with contributions from experts whose views differ to yours.

      2:56 AM - 24 Oct 2020
      • 2 Likes
      • Cindy Kinga Leon Of London
      4 replies 0 retweets 2 likes
        1. R Marcucio‏ @mcfunny 24 Oct 2020
          Replying to @lee_jjj @ENirenberg

          There is really no debate. The virus has been isolated and shown to cause covid19.

          0 replies 0 retweets 8 likes
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        1. Rosewind‏ @Rosewind2007 24 Oct 2020
          Replying to @lee_jjj @ENirenberg

          No, no he doesn’t. There isn’t “healthy debate” which involves people denying the science and telling lies.

          0 replies 0 retweets 18 likes
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        1. Christopher Visentin‏ @SwordtheChemist 24 Oct 2020
          Replying to @lee_jjj @ENirenberg

          if you mean that you people and your "experts" blab falsehood and ignorance, yup, that's about it!

          0 replies 0 retweets 5 likes
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        1. Vaccinated Grogu‏ @rjgerwin 24 Oct 2020
          Replying to @lee_jjj @ENirenberg

          Flat earth assertions are not “debate”

          0 replies 0 retweets 8 likes
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