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Prikvačeni tweet
New
#cryoEM work from the lab showing that the FANCD2-FANCI proteins are a clamp, locked onto dsDNA by ubiquitin.@palconh@ShabihShakeel@MRC_LMB https://www.biorxiv.org/content/10.1101/858225v1 …pic.twitter.com/zTylwJN82b
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Lori Passmore proslijedio/la je Tweet
It's a pleasure to put a spotlight on the beautiful Fanconi Anemia core complex structure by
@lapassmore lab and colleagues. Already, 2020 looks promising for more exciting structural biology breakthroughs around FA!
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(20)30009-8 …pic.twitter.com/y5RyiSjjq5
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Lori Passmore proslijedio/la je Tweet
‘We need a people’s cryo-EM.’ Scientists hope to bring revolutionary microscope to the masseshttps://www.sciencemag.org/news/2020/01/we-need-people-s-cryo-em-scientists-hope-bring-revolutionary-microscope-masses …
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Lori Passmore proslijedio/la je Tweet
Stem cells in silence and in action: Elaine Fuchs
@RockefellerUniv will give the 2019 César Milstein Lecture on Monday 27th January at 11.00am in the LMB’s Max Perutz Lecture Theatre#LMBnews https://www2.mrc-lmb.cam.ac.uk/cesar-milstein-lecture-to-be-given-by-elaine-fuchs/ …pic.twitter.com/ldCYSQRAZe
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Lori Passmore proslijedio/la je Tweet
Delighted to announce that the 2020 Machines on Genes registration is now open. It will take place May 3-7 in Alicante (Spain). We have a spectacular list of confirmed speakers and many slots for talks selected from abstracts. Register here: http://bit.ly/86Harden pic.twitter.com/3MvJx8mI1Q
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Lori Passmore proslijedio/la je Tweet
The application deadline for the 2020
@cshlcourses Cryo-EM course is less than two weeks away! We have a great two weeks planned with hands-on training and awesome lecturers. Info & application here: https://meetings.cshl.edu/coursesapplication.aspx?course=C-CRYOEM&year=20 … (retweet)Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
News and Views article by Michael Erb here: https://www.nature.com/articles/s41589-019-0428-x … and complementary work published by Kakegawa et alhttps://www.sciencedirect.com/science/article/pii/S0006291X19315062?via%3Dihub …
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It seems that cells with aberrant transcription are particularly sensitive to CPSF73 inhibition, offering a therapeutic window for using this as an anti-cancer therapy
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The target was discovered through unbiased phenotypic screening & extensive validation by
@Novartis and@FMIscience colleagues. They also found that JTE-607 acts as a prodrug. We played a small part by showing inhibition of 3' end cleavage in vitro@rodriguezmol@MRC_LMBPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Surprise finding that the CPSF endonuclease that cleaves pre-mRNAs to generate a 3'-end is the target of JTE-607, a compound that inhibits production of proinflammatory cytokines, & promotes cell death of AML/Ewing's sarcoma cell lines https://rdcu.be/bYLUp
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Lori Passmore proslijedio/la je Tweet
Looking to do exciting new science and progress to the next step in your career? We have a Senior Staff Scientist position available in functional genomics to help lead a team building genetic interaction maps. (https://jobs.sanger.ac.uk/vacancy/senior-staff-scientist-407933.html …). Part of
@DepMapSanger#Depmap. Please RTHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Lori Passmore proslijedio/la je Tweet
Not a household name, but
@MRC_LMB scientist Cyrus Chothia did much to build the theoretical framework of#structuralbiology and#bioinformatics.https://www.theguardian.com/science/2019/dec/12/cyrus-chothia-obituary …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
This is a really interesting study on the Integrator complex. Congratulations
@AdelmanLab !https://twitter.com/AdelmanLab/status/1202673372720586753 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Lori Passmore proslijedio/la je Tweet
Congratulations to Dr. Jernej Ule from and Dr. Igor Ulitsky (
@IgorUlitsky)--winners of our Mid and Early-Career Awards!! Read more here: https://www.rnasociety.org/News/2020-rna-society-early-and-mid-career-award-winners/ …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
I am particularly touched that this in memory of Elisa - she is deeply missed.
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This recognizes all of the amazing, innovative and sometimes brave work of past & present lab members! I am very grateful for the support of my colleagues and collaborators around the world, and
@MRC_LMB and@ERC_Research for supporting and believing in us!Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Wow! I feel incredibly honoured to be selected by
@RNASociety for the inaugural Elisa Izaurralde award.https://twitter.com/RNASociety/status/1202736831432802305 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
This is set to be an exciting conference for the DNA repair field!https://twitter.com/Laura_Fusion/status/1199357622983561222 …
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The Pavletich lab also reports a structure of the monoubiquitinated FANCD2-FANCI complex: https://www.biorxiv.org/content/10.1101/854133v1 … Exciting times for the Fanconi anemia, DNA repair and ubiquitin fields!
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We also determined a structure of FANCD2 alone and found it is a homodimer, in a closed conformation that cannot bind DNA with occluded monoubiquitination sites. We propose a model for how FANCD2 and FANCI act as a signal to recruit DNA repair factors.pic.twitter.com/r2prlAfcRW
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Ubiquitin (green) then acts as a molecular pin to lock the FANCD2-FANCI clamp on DNApic.twitter.com/p6blYAB5k1
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