Alex Kwan

@kwanalexc

New Haven, CT
alexkwanlab.org
Vrijeme pridruživanja: studeni 2013.
165 fotografija ili videozapisa Fotografije i videozapisi

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  1. Prikvačeni tweet
    7. sij

    Excited to share the lab's latest study of action on cortical dendritic spines in the mouse. Study was led by Farhan Ali, and supported by (thread follows)

    12 replies 68 proslijeđenih tweetova 202 korisnika označavaju da im se sviđa
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  2. 31. sij

    Hope the students will appreciate all the time I spent gathering memes for the data analysis lecture next week

    23 korisnika označavaju da im se sviđa
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  3. proslijedio/la je Tweet
    28. sij

    A clone in the developing cortex. A single neural stem cell labeled at E10 that gave rise to radial glia and newborn neurons in the different cortical layers at E18.5 .

    12 replies 99 proslijeđenih tweetova 547 korisnika označava da im se sviđa
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  4. 25. sij

    I can tag now 👍

    A very enjoyable dinner with ⁦⁩ ⁦⁩ Jane Taylor after Bruno Averbeck’s seminar.
    7 korisnika označava da im se sviđa
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  5. proslijedio/la je Tweet
    24. sij

    In anticipation of Robbie Burns Day, I present to you a Ballad on Mouse Decision-making. It is about a recent paper by

    16 proslijeđenih tweetova 82 korisnika označavaju da im se sviđa
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  6. proslijedio/la je Tweet
    23. sij

    New work out : simultaneous opto-activation/silencing and voltage imaging to reveal circuit mechanism-a lateral inhibitory L1 circuit for winners-takes-all dynamics. Kudos to my amazing graduate advisor , collaborators, and co-authors!

    New Article online now at Cell: All-Optical Electrophysiology Reveals the Role of Lateral Inhibition in Sensory Processing in Cortical Layer 1
    16 replies 27 proslijeđenih tweetova 106 korisnika označava da im se sviđa
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  7. 23. sij

    The lab got a Vidrio rapid multi-region scanner. Looking forward to seeing dendritic branch dynamics with this unit. 👀

    1 reply 30 korisnika označava da im se sviđa
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  8. proslijedio/la je Tweet
    18. sij

    I am frequently asked by students about transition into "independence in science", the ability "to do things alone". I want to challenge that concept and argue that framing training as path towards "independence" is confusing for many. True "independence"="interdependence"(1/n)

    9 replies 145 proslijeđenih tweetova 556 korisnika označava da im se sviđa
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  9. proslijedio/la je Tweet
    18. sij

    My paper is out on ! We explored movement signals in visual cortex and found a lot of surprising things.

    Encoding of 3D Head Orienting Movements in Primary Visual Cortex
    50 proslijeđenih tweetova 135 korisnika označava da im se sviđa
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  10. proslijedio/la je Tweet
    15. sij

    Very happy to share this preprint from my main PhD project. We performed wide-field calcium imaging on animals solving both auditory and tactile discrimination tasks with a delay. Many thanks to , , Balazs Laurenczy and Fabian Voigt .

    Wondering how cortical signal flow depends on the task your doing and on your strategy in individual trials? Check out our new preprint at . Many thanks to Yasir Gallero-Salas, , and all co-authors.
    13 proslijeđenih tweetova 30 korisnika označava da im se sviđa
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  11. proslijedio/la je Tweet
    10. sij

    Excluding techs from authorship is classism. If the argument is that they're getting paid to do it because it's their job, then the PI shouldn't be an author either.

    272 proslijeđena tweeta 2.163 korisnika označavaju da im se sviđa
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  12. 10. sij

    The lecture delivered by with an eye to the future.

    7 korisnika označava da im se sviđa
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  13. 10. sij

    The inaugural George Heninger lecture ⁦⁩ ⁦⁩

    1 reply 2 proslijeđena tweeta 12 korisnika označava da im se sviđa
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  14. proslijedio/la je Tweet
    9. sij

    Very happy that this review with on gain regulation in the cortex is now out online!

    What are the mechanisms that modulate gain in the ? Check out this latest Review by and
    1 reply 12 proslijeđenih tweetova 72 korisnika označavaju da im se sviđa
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  15. 7. sij

    I mistyped the handle for - who I should also mention has a highly related study on how the same SST-neuron manipulations influence depressive-like behaviors /end+1

    1 reply 1 proslijeđeni tweet 1 korisnik označava da mu se sviđa
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  16. 7. sij

    As calcium is essential for dendritic spine plasticity, we think the ketamine-elevated calcium influx may be a necessary precursor to the subsequent structural remodeling in the frontal cortex. /end

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  17. 7. sij

    The dendritic disinhibition caused by ketamine altered behavior and increased long-range cortico-cortical connectivity.

    1 reply 2 proslijeđena tweeta 6 korisnika označava da im se sviđa
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  18. 7. sij

    Why would ketamine increase calcium in spines? Collaborating with @dmgerhar and Ron Duman, we did causal manipulation of GluN2B to show that this was due to ketamine's suppressive effects on dendrite-targeting SST interneurons.

    1 reply 1 proslijeđeni tweet 3 korisnika označavaju da im se sviđa
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  19. 7. sij

    To show that the elevated calcium can be synaptically evoked, Farhan did a difficult experiment combining electrical stimulation and spine imaging. (Probably my favorite figure in the whole paper 😀)

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  20. 7. sij

    Here we found that a single, antidepressant-level dose of ketamine increases spontaneous calcium transients in dendritic spines in the mouse frontal cortex.

    1 reply 4 proslijeđena tweeta 4 korisnika označavaju da im se sviđa
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  21. 7. sij

    The study was a 'functional' follow-up to our previous structural imaging study of ketamine’s effect on spine formation rates.

    1 reply 3 korisnika označavaju da im se sviđa
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