Katherine Xue

@ksxue

Postdoc with and studying evolution in the microbiome. Formerly grad student with studying influenza.

Vrijeme pridruživanja: lipanj 2009.

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  1. Prikvačeni tweet
    21. lis 2019.

    My new study with comparing influenza's evolution within and between hosts is on bioRxiv! (1/n)

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  2. proslijedio/la je Tweet
    21. lis 2019.

    Our new study led by explores how flu evolution within infected humans relates to viral evolution at the global scale. has posted a nice Twitter summary linked to in this tweet, so I'll just add a few figures that also encapsulate the key results. (1/4)

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  3. 21. lis 2019.

    Excited to hear your comments and feedback! (n/n)

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  4. 21. lis 2019.

    Based on these analyses, selection against deleterious, nonsynonymous mutations and selection for antigenic mutations are the major forces that transform within-host diversity into global evolutionary change. (8/n)

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  5. 21. lis 2019.

    The major exception to this trend is antigenic mutations. They're present at the same frequencies as background genetic variation within hosts, but they fix quickly on a global scale. (7/n)

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  6. 21. lis 2019.

    Most nonsynonymous mutations that we see within hosts are probably transient, deleterious mutations. They can reach detectable frequencies within hosts, but they are purged later by purifying selection at transmission and early in global evolution. (6/n)

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  7. 21. lis 2019.

    Nonsynonymous mutations are interesting: they accumulate more slowly globally than they do within hosts. (5/n)

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  8. 21. lis 2019.

    Synonymous mutations accumulate at similar rates within and between hosts, showing that flu's genetic diversity at mostly neutral sites within hosts is on par with its global evolution. (4/n)

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  9. 21. lis 2019.

    We compared flu's evolution within and between hosts by calculating evolutionary rates, which give us a simple, quantitative framework for comparing viral diversity. (3/n)

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  10. 21. lis 2019.

    Recently and others have deep sequenced flu infections and identified mutations within hosts. But what happens to these within-host mutations in the global flu population? (2/n)

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  11. proslijedio/la je Tweet
    29. ruj 2019.
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  12. proslijedio/la je Tweet
    13. svi 2019.

    Come to the thesis defense of superstar grad student ( ) at 2 PM today in Foege auditorium to hear about the evolution of flu within and between hosts. (And for anyone who looked at my first tweet, it's in Foege, not Pelton).

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  13. 25. velj 2019.

    Our comparison of influenza deep-sequencing studies is out in . Results support low diversity and a narrow transmission bottleneck during acute flu infections. Previous discrepancies arose from a technical problem.

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  14. 22. sij 2019.

    Excited to be leading this book club with and starting February 12 ! You can build so much with 25 copies of The Origin of Species...

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  15. proslijedio/la je Tweet
    26. pro 2018.

    Delighted that has chosen to come to Stanford to join my and 's labs! Excited about all the cool science we will do together. Woohoo!

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  16. proslijedio/la je Tweet
    13. pro 2018.

    Congrats to for being selected for the James Crow early-career scientist symposium. If you are at Univ Wisconsin-Madison, be sure to check out her Jan 31 talk on the evolution of flu at within-host versus global scales:

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  17. 25. lis 2018.

    Thanks for the clarification on art attribution!

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  18. 25. lis 2018.

    people: What are good resources for learning more about ecology, microbe to macrobe? Just in case you fall asleep reading 's book, that is.

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  19. 24. lis 2018.

    Thanks for great discussions of community dynamics, cooperation, host-pathogen interactions, the evolution of multicellularity, and much more at at ! Here's a word cloud of my notes in the style of the lovely logo by .

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  20. proslijedio/la je Tweet

    . finds clonal interference and highly repeatable mutations in human flu from time-series patient data. Selection acting within-host drives global flu diversity.

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