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Prikvačeni tweet
Seeing already multiple downloads of full summary stats for our latest
#epigenome-wide association study with blood proteins w/@SomaLogic &@illumina 450k .. Large potential for#Mendelian#Randomization - check out https://wcmq.app.box.com/s/f85fxv9ldvsshd1b1d0qbfwde75no1x4 … and https://www.nature.com/articles/s41467-019-13831-w …#proteomicsPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Karsten Suhre proslijedio/la je Tweet
The
is on!
Doing stool #metabolomics#lipidomics? Want to know which metabolites are reproducible? We tested in this paper: https://rdcu.be/b0XPI 10 healthy volunteers, 1 stool sample, cryogenically drilled 4 times 185 molecules, high variation btw drill & btw participantspic.twitter.com/ijBdw32DNh
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Karsten Suhre proslijedio/la je Tweet
R scientists: What's your most beautiful multipanel plot produced in ggplot? I'm looking for impressive examples to show my R class on Monday. Brag to me!
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Karsten Suhre proslijedio/la je Tweet
Rich data sets could end costly drug discovery https://www.nature.com/articles/d41586-020-00200-7 …
@segal_eran explains why it’s time to go beyond genetics when developing drugs. Deep Phenotyping including#metabolomics is a better approach.Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Karsten Suhre proslijedio/la je Tweet
Appreciate
@LocasaleLab’s strong contributions to transcriptome-level analysis of mammalian cell#metabolism. No doubt next frontier, but before everyone goes nuts, remember: “Metabolism is a whole additional layer of regulation with enzymes that have to do chemical reactions.”https://twitter.com/NCIgenomics/status/1223637327467118593 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Karsten Suhre proslijedio/la je Tweet
Differences in the metabolic activity observed in single cells versus bulk tumors;
@LocasaleLab on single-cell metabolism analyseshttps://www.cancer.gov/about-nci/organization/ccg/blog/2020/interview-metabolism …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Karsten Suhre proslijedio/la je Tweet
Easily catch up genetic association studies in the world for kidney function by reading this editorial by
@CristianPattaro and Dr. Anna Köttgen.#gwas#kidney#CKDGenhttps://www.kidney-international.org/article/S0085-2538(19)31131-7/abstract …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Karsten Suhre proslijedio/la je Tweet
Here we show that children presumed to have Mendelian forms of disease are often just a higher polygenic risk. I wonder how many undiagnosed children with "rare genetic Mendelian diseases" are just at higher polygenic risk? https://asbmr.onlinelibrary.wiley.com/doi/pdf/10.1002/jbmr.3956 …
#PolygenicRiskHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Karsten Suhre proslijedio/la je Tweet
I’m thrilled to announce the publication of the quantitive proteomic profiling of the Cancer Cell Line Encyclopedia. The
@GygiLab in collaboration with colleagues at Novartis and the Broad we measured the proteomes of 375 cell lines from various tumor lineages (1/13)pic.twitter.com/WXgsODMzFs
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Karsten Suhre proslijedio/la je Tweet
I probably should have put it in the first tweet, but the manuscript is available at https://www.cell.com/cell/fulltext/S0092-8674(19)31385-6 … !
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Karsten Suhre proslijedio/la je Tweet
What an exceptional webinar the
@EMN_MetSoc has in store for you next week!@ksuhre will be presenting his work on 'Human metabolic individuality and its role in multi-omics based studies'. Spread the word and register here:https://register.gotowebinar.com/register/6983380282840541195 …https://twitter.com/EMN_MetSoc/status/1221790535016501249 …
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Merci pour la traduction
https://twitter.com/rfmf_junior/status/1222547189236408323 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Would be interesting which small signaling molecules are in play here
#metabolomicshttps://twitter.com/neurosocialself/status/1221795569946857472 …
0:28Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Karsten Suhre proslijedio/la je Tweet
“These latest findings further emphasize the importance of studying vitamin signaling pathways in cancer.”http://bit.ly/2RxoZwL
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Karsten Suhre proslijedio/la je Tweet
I <3 studies like this that focus on integration of multiple -omics techniques to understand the big picture. This study used epigenetics and proteomics to understand how DNA methylation can affect the proteome and cause disease.https://www.nature.com/articles/s41467-019-13831-w …
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Karsten Suhre proslijedio/la je Tweet
In a recent study fueled by Metabolon,
@ksuhre,@timspector et. al., identified 11 distinct genetic loci regulating the level of 14 salivary metabolites. Extra novel associations were identified allowing for an expansion of knowledge on genetic influences in human metabolites.https://twitter.com/ksuhre/status/1219993470514946049 …
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Karsten Suhre proslijedio/la je Tweet
I'm excited to dig into this new urinary metabolites GWAS: https://www.ncbi.nlm.nih.gov/pubmed/?term=31959995 …. But I'm having trouble getting past the first hit. Why would you annotate rs3980014 with CASP9 when you have that beautiful AGMAT right there
@ksuhrepic.twitter.com/OakgBvbr0c
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Karsten Suhre proslijedio/la je Tweet
Since to me this is the most interesting part of the study, I would have annotated the SNPs with the true causal genes and used those in the enrichment analyses. I agree with your 8 manual corrections from the supplementary notespic.twitter.com/uLu6yFYWGL
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Karsten Suhre proslijedio/la je Tweet
Ah - sorry - just found this footnote: "Incorporation of existing biochemical and biological knowledge would have led to prioritization of another most likely causal gene in the locus than the one derived by the automated scoring algorithm that is agnostic to gene function"
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Karsten Suhre proslijedio/la je Tweet
Congrats to
@ksuhre,@timspector@metabolon and collaborators on the publication of their saliva metabolite QTL study: https://www.ncbi.nlm.nih.gov/pubmed/31960908 Below is my favorite novel finding (DPYS geen) which I illustrated following their submission to@biorxivpreprint last year.https://twitter.com/Eric_Fauman/status/1147843005950435330 …
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Karsten Suhre proslijedio/la je Tweet
Interesting approach - Takeda tasks Charles River with sorting through its many early stage assetshttps://www.outsourcing-pharma.com/Article/2020/01/21/Takeda-forms-drug-discovery-pact-with-Charles-River …
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via Mehdi Moussaid