Very very very happy for the first paper of 2020 with @BrainSelf published at Journal of Neuroscience @SfNJournals! #tickleme @MSCActionshttps://www.jneurosci.org/content/40/4/894 …
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(2/n) It has been proposed that internal models predict the touch produced by our movements and cancel/attenuate the sensory reafference: https://www.cell.com/current-biology/pdf/S0960-9822(01)00432-8.pdf … http://learning.eng.cam.ac.uk/pub/Public/Wolpert/Publications/BayWol_AP_07.pdf …
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(3/n) Ok, but what about the neural correlates of this attenuation? An earlier study (N=6) found decreased activity in bilateral SII and in CB contralateral to the touched hand: https://www.nature.com/articles/nn1198_635 … But the CB contains ipsilateral body representations:https://www.nature.com/articles/nrn1347 …
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(4/n) Here we scanned 30 participants while they received self-generated or externally generated touches (see paper for additional conditions). We also managed to place a DC motor inside the scanner room and survive :)pic.twitter.com/sRM9ldiQ44
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(5/n) After the scanning, participants performed the force-matching task: https://www.ncbi.nlm.nih.gov/pubmed/12855800 . We replicated the classic behavioural effects of somatosensory attenuation.pic.twitter.com/fZXBMGpQsG
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(6/n) We found an attenuated activity in bilateral secondary somatosensory areas when the touch was presented during a self-generated movement (self-generated touch) than in the absence of movement (external touch).
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(7/n) An additional attenuation effect was observed in the cerebellum that is ipsilateral to the passive limb receiving the touch - which fits earlier neuroanatomical findings.pic.twitter.com/JA3lhICxOG
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(8/n) Importantly, we found that the degree of functional connectivity between the ipsilateral CB and the contralateral S1 and bilateral SII was linearly and positively related to the degree of attenuation; stronger attenuation, stronger connectivity!pic.twitter.com/y5g3advRs7
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(9/n) We conclude that the ipsilateral cerebellum is involved in predicting self-generated touch and in representing somatosensory attenuation via its functional connectivity with somatosensory areas.
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(10/n) SPOILER ALERT: here, we used the same analysis as that used by Blakemore which factors out the motor influences. For the sensorimotor connectome of somatosensory attenuation, stay tuned… it is coming!!!
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