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kimmaicutler's profile
Kim-Mai Cutler
Kim-Mai Cutler
Kim-Mai Cutler
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@kimmaicutler

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Kim-Mai CutlerVerified account

@kimmaicutler

Partner at @initialized. Previously @techcrunch. When life hands me lemons, I make tarte au citron.

San Francisco
medium.com/initialized-ca…
Joined April 2008

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    1. Apoorva Mandavilli‏Verified account @apoorva_nyc Jul 26
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      A very few people may not make antibodies at all. But they will still have immunity from T cells, which can recognize, remember and kill viruses. Again, how cool is the immune system? 6/xhttps://www.nytimes.com/2020/07/22/health/covid-antibodies-herd-immunity.html …

      1 reply 13 retweets 55 likes
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    2. Apoorva Mandavilli‏Verified account @apoorva_nyc Jul 26
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      This blew my mind: *several* tests — including ones made by @Roche and @AbbottNews, used by Quest/ @LabCorp -- test for antibodies to the nucleocapsid (N) rather than to the receptor binding domain (RBD) of the spike (S) protein, or the “business” end of the virus. Why? 7/x

      1 reply 15 retweets 42 likes
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    3. Apoorva Mandavilli‏Verified account @apoorva_nyc Jul 26
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      The N protein is plentiful, so antibodies to it produce an early bright signal—which is great for test makers in terms of showing a high sensitivity. But some reports now suggest N antibodies may also wane faster than antibodies to the spike or RBD. 8/x

      2 replies 8 retweets 31 likes
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    4. Apoorva Mandavilli‏Verified account @apoorva_nyc Jul 26
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      Even if that turns out not to be true – most of the time N and S antibodies have similar kinetics – it is just confusing for companies to be testing for antibodies that have little to do with immunity. 9/x

      1 reply 5 retweets 23 likes
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    5. Apoorva Mandavilli‏Verified account @apoorva_nyc Jul 26
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      So… bottom line, if you had confirmed Covid (ie, not if you just thought you had it), chances are pretty good that you have some protection from the virus, *even* if you got a negative antibody test. 10/x

      4 replies 13 retweets 56 likes
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    6. Apoorva Mandavilli‏Verified account @apoorva_nyc Jul 26
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      Sorry for the long thread but immunology is complicated! Huge thanks to @michaelmina_lab, Fiona Havers, @VirusesImmunity @angie_rasmussen for their patience and expertise, and @JBerz_MD for sharing his story. Please read the full article:https://www.nytimes.com/2020/07/26/health/coronvirus-antibody-tests.html …

      10 replies 16 retweets 85 likes
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    7. Kim-Mai Cutler‏Verified account @kimmaicutler Jul 26
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      Replying to @apoorva_nyc @Roche and

      How long after symptoms start would you test positive for?

      2 replies 0 retweets 1 like
    8. Apoorva Mandavilli‏Verified account @apoorva_nyc Jul 26
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      Replying to @kimmaicutler @Roche and

      Good question. Some papers have said antibody levels in some people drop 2-3 months after

      1 reply 0 retweets 2 likes
    9. Kim-Mai Cutler‏Verified account @kimmaicutler Jul 26
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      Replying to @apoorva_nyc @Roche and

      What about a regular non-antibody test?

      1 reply 0 retweets 0 likes
    10. Apoorva Mandavilli‏Verified account @apoorva_nyc Jul 26
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      Replying to @kimmaicutler @Roche and

      Not sure I understand your question

      1 reply 0 retweets 0 likes
      Kim-Mai Cutler‏Verified account @kimmaicutler Jul 26
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      Replying to @apoorva_nyc @Roche and

      Oh I meant if you took a coronavirus test but your symptoms had disappeared a say a week or so earlier, which test would you take?

      7:54 AM - 26 Jul 2020
      1 reply 0 retweets 0 likes
        1. Apoorva Mandavilli‏Verified account @apoorva_nyc Jul 26
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          Replying to @kimmaicutler @Roche and

          Oh, I see. I wouldn't bother with a PCR test at that point. Wait a couple of weeks and take an antibody test

          0 replies 0 retweets 2 likes
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