This meta-analysis seems unbiased: https://www.medrxiv.org/content/10.1101/2020.05.14.20101774v1 … Certainly better evidence than "See India"!
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Need to look at the timing of the delivery for each case they review, studies where they give it to already hospitalized / well developed cases should be discredited, whole point is it needs to be early
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Replying to @rivatez @stuartbuck1 and
And yes India is interesting - government intiative to give it as a prophylactic to medical workers and widespread usage in certain high density slums? sounds like the biggest global trial... not sure why you would want to ignore it
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Without a counterfactual and without reliable testing data, I'm not sure what we can possibly learn from India here.
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Seems like they shelved that plan too. https://abcnews.go.com/Health/wireStory/trumps-malaria-drug-combat-virus-spurs-india-boon-70758373 …pic.twitter.com/eC8oGifAz9
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Riva Retweeted James Todaro, MD
here's some of those 'shelved plans' data coming through-https://twitter.com/JamesTodaroMD/status/1263148644556996610?s=20 …
Riva added,
James Todaro, MDVerified account @JamesTodaroMDIndia offered HCQ prophylaxis to 10,000 Mumbai policemen. About 4,500 routinely took HCQ, while 5,500 refused. RESULTS: HCQ group: 0 deaths Non-HCQ group: 9 deaths And those who contracted COVID-19 in the HCQ group had "mild attacks" h/t@niro60487270 https://timesofindia.indiatimes.com/city/mumbai/toll-climbs-to-9-cops-on-hcqs-spared-the-worst/articleshow/75845670.cms …1 reply 0 retweets 1 like -
Replying to @rivatez @kimmaicutler
This is nowhere near as good as a controlled experiment. People who adhere to treatment do better even when it's a placebo (they're more conscientious generally). Classic example from the medical literature (note the survival rates in the placebo group):https://pubmed.ncbi.nlm.nih.gov/6999345/
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Randomized, placebo-controlled, double-blinded trial on early use of HCQ as a preventative: no benefit.https://www.washingtonpost.com/health/2020/06/03/hydroxychloroquine-clinical-trial-results/ …
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Replying to @stuartbuck1 @kimmaicutler
Sharing a WaPo article when the study isn’t even out yet? And considering both you and NEJM were touting a ‘nail in the coffin’ study that proved to be unbelievably fraudulent, I’ll wait to make up my own decisions :)
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Replying to @rivatez @kimmaicutler
Not me! :) I would never plug an observational study in the Lancet of all places (going at least back to the Andrew Wakefield vaccine study, they aren't that good at catching obvious errors).
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Replying to @kimmaicutler @rivatez
Stuart Buck Retweeted Stuart Buck
Sad #1: that HCQ doesn't work, as we could really use an effective treatment. Sad #2: the meta-cognitive failure in
@rabois being so certain that the VC mentality is a useful way to approach clinical medicine.https://twitter.com/stuartbuck1/status/1243240228451647491 …Stuart Buck added,
Stuart Buck @stuartbuck1In addition to what@Jabaluck has pointed out, I wonder if part of the problem with@rabois comments about RCTs is that some VCs become very successful by having good contrarian instincts and then getting lucky a few times. https://twitter.com/rabois/status/1243215225823744000 …Show this thread0 replies 0 retweets 0 likesThanks. Twitter will use this to make your timeline better. UndoUndo
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