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Tremendously excited by the way deep learning can transform protein fitness landscapes into more-evolvable topologies with just (all proteins) + (related proteins) + (lab data from a few dozen random mutants)https://twitter.com/grigonomics/status/1220768850834284544 …
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Mice Against Ticks: an ecological and community-guided approach to preventing Lyme that starts small before scaling up (no
#genedrive). Honored to work with local supporters, skeptics, collaborators, and first author Joanna Buchthal! https://royalsocietypublishing.org/doi/full/10.1098/rstb.2018.0105 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
In an era of increasingly powerful and accessible technologies, we can't afford big mistakes. Why keeping
#CRISPR#genedrive nonprofit will help us make wiser decisions on whether, when, and how to move forwards.#UNBiodiversity#COP14https://bit.ly/2r7oj35Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
An elegant and comprehensive story by
@chorye & co elucidates the key role of nucleosome turnover in regulating gene expression. Check out the clear/concise walkthrough thread; if all papers had this rather than just abstract/fulltext, reading the literature would be far easier.https://twitter.com/chorye/status/1065278169819897856 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
I’ve called for critics of
#genedrive to support transparency & community guidance of research http://www.councilforresponsiblegenetics.org/GeneWatch/GeneWatchPage.aspx?pageId=584 …. Don’t take away options; ensure people can voice concerns & help make decisions.#COP14#UNBiodiversityPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Even conducting
#genedrive research in the traditional closeted manner is ethically suspect because it denies people a voice in early-stage decisions intended to affect them. We can and should pioneer a new model of#openscience.#COP14#UNBiodiversityPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Anyone launching a for-profit corporation intending to use
#genedrive at this stage is jeopardizing critical humanitarian applications and putting lives (and species) at risk.#COP14#UNBiodiversityPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
If a
#genedrive application is important, it can likely be accomplished by a nonprofit w/ philanthropic & gov’t support. It’s harder for communities to trust people with financial incentives, so why risk the potential benefits?#COP14#UNBiodiversityPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
In my opinion, all CRISPR-based
#genedrive research and applications should be nonprofit for the foreseeable future. To those concerned the technology might cement the dominance of giant agribusiness: not if I can help it.#COP14#UNBiodiversityPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Thanks! Will answer more later tonight after I put the kids to bed.https://twitter.com/JFBonnefon/status/1013887965574127617 …
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Questions on
#genedrive, open science, or the strange doings of mice and ticks?#Reddit#askscience#AMA today@2pm EThttps://www.reddit.com/r/askscience/comments/8vhr0k/askscience_ama_series_im_kevin_esvelt_head_of_the/ …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Mice Against Ticks: striving to prevent Lyme disease, pioneer community-directed science, and avoid creating a real-world mishap worthy of a John Oliver limerick since 2016.https://www.youtube.com/watch?v=AJm8PeWkiEU&t=13m40s …
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We celebrate interventions in nature that prevent human suffering, even extinctions. Smallpox is gone; polio & malaria may follow. But are we obligated to intervene for the sake of other animals? The answer may define who we are.https://leapsmag.com/when-are-we-obligated-to-edit-wild-creatures/ …
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Rowan's conclusion is poignant and haunting, a paean to the beauty of things-as-they-are. Yet nature is also rife with suffering. With the power to intervene comes moral responsibility for the consequences, even if we choose restraint.
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Thoughtful piece by
@rowanjacobsen on#genedrive. Caveat: models suggest drive cannot eliminate a species without sustained human intervention. That is why every affected country's support will likely be needed to eradicate malaria.https://psmag.com/magazine/deleting-a-species-genetically-engineering-an-extinction …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
To anyone who doubts our results on the invasiveness of self-propagating
#genedrive: please let us and the world know. Approval for any field trial is unlikely absent conclusive evidence refuting our models, so I earnestly hope we are proven wrong. 4/4Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
To anyone working on self-propagating
#genedrive for an application other than malaria: is there a path to real-world approval and benefits? If you think so, make a public case for it! Openly engaging communities from the outset is the best way forwards. 3/4Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Why is malaria different from other
#genedrive applications? Eradication requires hitting all major mosquito vectors in Africa, and international agreement should be possible without field trials. A few other cases may exist, but none so obvious. 2/4Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
New paper: Our default expectation is that self-propagating
#genedrive will invade most populations of the target species around the world. Unless fighting malaria, best not to build one that can spread in the wild. https://elifesciences.org/articles/33423 1/4Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Many thanks to the
#Nantucket Board of Health for organizing the filmed event, to the Steering Committee members who volunteered to direct the project, to the NOVA team, and to all community members who have participated by sharing suggestions & concerns.Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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- a framework for low-N protein engineering with data-efficient deep learning! Had a blast working with brilliant