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kerpen's profile
Phil Kerpen
Phil Kerpen
Phil Kerpen
Verified account
@kerpen

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Phil KerpenVerified account

@kerpen

Husband. Father of four. @AmerComm and @Comm4Prosperity president. Syndicated columnist. IFC chairman. Mets fan.

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Joined June 2007

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    Phil Kerpen‏Verified account @kerpen Apr 13

    Phil Kerpen Retweeted Klaus K

    This is a surprising result. Smokers are far LESS likely to be hospitalized with COVID-19 that non-smokers and it looks robust across countries. Why might this be?https://twitter.com/KlausKblog/status/1249048902495592450 …

    Phil Kerpen added,

    Klaus K @KlausKblog
    Official French data on #tobacco smoking & #covid19 replicate the picture in China, Germany & USA: A remarkable low rate of smokers are hospitalised w/ coronavirus compared to smoking prevalence (France 23%). https://fr.calameo.com/read/0062175782dac24c23c92 … https://twitter.com/KlausKblog/status/1245544033272938496 … pic.twitter.com/8MMMfhriGx
    7:56 AM - 13 Apr 2020
    • 1,837 Retweets
    • 3,650 Likes
    • Tony نعیم AbdulhaySelim Dündar All Out of Bubblegum Orxan Evan Schoenbach Niloo walidbey Jorge C KOZO
    603 replies 1,837 retweets 3,650 likes
      1. New conversation
      2. Phil Kerpen‏Verified account @kerpen Apr 13

        The US data from CDC is... well shocking. Almost literally unbelievable.pic.twitter.com/kwJr3RVWlg

        62 replies 312 retweets 683 likes
        Show this thread
      3. Phil Kerpen‏Verified account @kerpen Apr 13

        Only 1.3% of U.S. COVID-19 cases are current smokers. Only 2.3% are former smokers.

        61 replies 277 retweets 671 likes
        Show this thread
      4. Phil Kerpen‏Verified account @kerpen Apr 13

        Possible explanation? Nicotine lowers ACE2 expression. (SARS-CoV-2 uses ACE2 for entry into target cells.) https://ncbi.nlm.nih.gov/pmc/articles/PMC6295500/ …pic.twitter.com/Jg1u0ynUzu

        38 replies 242 retweets 694 likes
        Show this thread
      5. Phil Kerpen‏Verified account @kerpen Apr 13

        Phil Kerpen Retweeted Leora Horwitz

        One major New York hospital system that has released its data has a lot more smoking than the CDC data, but notably they have the odds ratio for tobacco use at less than 1.https://twitter.com/leorahorwitzmd/status/1249319859378405377 …

        Phil Kerpen added,

        Leora HorwitzVerified account @leorahorwitzmd
        Male sex is still a risk for hospitalization even after adjustment: OR 2.8. Note what is not, though: hypertension (OR 1.2 not sig), COPD/asthma (OR 1.3, not sig), current/former smoking (OR 0.7). Don't understand the smoking results yet, looking more at this.
        Show this thread
        7 replies 39 retweets 152 likes
        Show this thread
      6. Phil Kerpen‏Verified account @kerpen Apr 13

        Contra the theory above, a study from China finds higher ACE2 expression in smokers.https://www.medrxiv.org/content/10.1101/2020.03.18.20038455v1 …

        5 replies 21 retweets 116 likes
        Show this thread
      7. Phil Kerpen‏Verified account @kerpen Apr 13

        Question for the biochemists... *if* (big if!) there is a nicotine protective effect, is there an analog or derivative that could produce the same effect without the harms of nicotine?

        49 replies 32 retweets 197 likes
        Show this thread
      8. Phil Kerpen‏Verified account @kerpen Apr 13

        Phil Kerpen Retweeted Trevor Sutcliffe

        Another more complex theory of the potential mechanism, this one more consistent with the recent study in China.https://twitter.com/TrevorSutcliffe/status/1249767401899454470 …

        Phil Kerpen added,

        Trevor Sutcliffe @TrevorSutcliffe
        Replying to @kerpen
        Hi, Phil. I believe the explanation here is that the smoke itself causes the lungs to increase expression of mucus-secreting cells high in ACE2. ACE2 converts Ang-II (vasoconstrictive, pro-inflammatory) into Ang-(1-7) (vasodilatory, anti-inflammatory). https://twitter.com/TrevorSutcliffe/status/1245431205605953536 … pic.twitter.com/KTCvRUIN2n
        7 replies 33 retweets 104 likes
        Show this thread
      9. Phil Kerpen‏Verified account @kerpen Apr 13

        Several respondents have pointed me to this paper coauthored by Dr. Raymond Niaura, Interim Chair of the Department of Epidemiology at NYU. https://www.qeios.com/read/article/561 …pic.twitter.com/xd8JG8fs4C

        10 replies 19 retweets 72 likes
        Show this thread
      10. Phil Kerpen‏Verified account @kerpen Apr 13

        Should note this disclaimer on the U.S. data from CDC. Let's see what the next update looks like.pic.twitter.com/0OTC8qzTNz

        12 replies 15 retweets 58 likes
        Show this thread
      11. Phil Kerpen‏Verified account @kerpen 7h7 hours ago

        Phil Kerpen Retweeted Klaus K

        There's a preprint on that French hospital data now.https://twitter.com/KlausKblog/status/1252418954435256326 …

        Phil Kerpen added,

        Klaus K @KlausKblog
        French study confirms world trend: Smokers 5 times less likely to be #covid19 patients. "Our study strongly suggests that daily smokers have a much lower probability of developing symptomatic or severe covid19 infection compared to the general population." https://www.qeios.com/read/article/569 …
        Show this thread
        3 replies 4 retweets 7 likes
        Show this thread
      12. End of conversation

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