Medijski sadržaj
- Tweetovi
- Tweetovi i odgovori
- Medijski sadržaj, trenutna stranica.
-
We then targeted recordings from individual neurons a parietal cortex homolog (AM), and found that cells responded more strongly to the cursor when mice were controlling it than when passively viewing it, especially when the cursor was close to the target.pic.twitter.com/1wKWrBcpHo
Prikaži ovu nit -
We found that parietal and higher visual cortical regions were more engaged when expert animals controlled the cursor, but not in naïve mice learning the task. Interestingly, parietal cortex has been shown in human studies to be involved in a sense of agency over one’s body.pic.twitter.com/rUkqqauBsB
Prikaži ovu nit -
Animals therefore had to learn new activity patterns necessary for successful BMI control each session. They did this by first stochastically exploring neural activity space for patterns that could achieve hits, then exploited the successful pattern to reliably reach the target.pic.twitter.com/HXFEnSAj3a
Prikaži ovu nit -
Here we devised a brain machine interface (BMI) task, in which mice learned to guide a visual feedback cursor to a target location for reward, using activity in brain areas recorded with widefield calcium imaging–acting as a survey of dorsal cortex throughout learning.pic.twitter.com/bpNX40IJpC
Prikaži ovu nit -
Thread: I’m pleased to share my new paper, wherein we devised a novel optical brain machine interface (BMI) to investigate how the brain infers and controls a causal relationship between its activity and the outside world. https://www.biorxiv.org/content/10.1101/786467v1 …pic.twitter.com/HfdeGKtnPy
Prikaži ovu nit -
But when animals started walking, the neurons in retrosplenial cortex became much less locally correlated, and instead coupled to distant sensory and motor areas.pic.twitter.com/XGozs8wIbn
Prikaži ovu nit -
Rather than diffusely modulating the activity of cells, at least some long range projections may directly drive neurons in their target areas—so, in a local network, some neurons may act as ‘local representatives’ of activity happening in distant areas, in a small-world manner.pic.twitter.com/SqQViAlua5
Prikaži ovu nit -
We then correlated the spike trains of each neuron with the activity across the rest of the brain to build a kind of correlation ‘heat map’ we call SpAMs (Spike-triggered Activity Maps). Here are example SpAMs from 8 different cortical neurons:pic.twitter.com/hjGB9tLoZ3
Prikaži ovu nit -
Or do neurons independently couple to different areas depending on task demands or behavioral state?pic.twitter.com/IqxWbVyLBg
Prikaži ovu nit -
But this only tells us about populations of neurons--how do individual neurons link up with activity in distant networks? For example, do dedicated populations of neurons in an area project to a given target, and these populations get turned on/off when they aren’t needed?pic.twitter.com/HSxtP539Kk
Prikaži ovu nit -
An example of this is the default mode network (green), an evolutionarily conserved collection of brain areas that become active when a subject is at rest. When the subject becomes mentally engaged in something, different areas turn on (visual attention network in red, Raichle).pic.twitter.com/I1413CywEE
Prikaži ovu nit -
to mapping the large scale patterns of white matter, bundles of axons passing information between areas (diffusion tension imaging from Thomason and Thompson, 2011)pic.twitter.com/0FTKnqXNk4
Prikaži ovu nit -
Scientists have spent years mapping such projections anatomically, using a slew of methods: from tracing individual neurons projecting within the brain (from the
@AllenInstitute)pic.twitter.com/nziV0IzTw7
Prikaži ovu nit -
I accidentally plotted instead of grey-scaled a dorsal image of cortex and it looks like thispic.twitter.com/PpbVo0tgkp
-
-
Čini se da učitavanje traje već neko vrijeme.
Twitter je možda preopterećen ili ima kratkotrajnih poteškoća u radu. Pokušajte ponovno ili potražite dodatne informacije u odjeljku Status Twittera.