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Kaur Alasoo proslijedio/la je Tweet
If you like the look and feel of the Open Targets Platform, maybe you might also be interested in helping develop it further? Here's an opportunity:https://twitter.com/targetvalidate/status/1223282699101769728 …
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Kaur Alasoo proslijedio/la je Tweet
What
@sorahill asks has been done, with null results, (&many caveats ) by world leading team of Jensen, Ajslev, Brunak & Sørensen. Sad that in this over-hyped literature such ingenious studies answering the "is there a question?" question are ignored https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680005/ …https://twitter.com/sorahill/status/1220632741676449792 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Population variation of miRNAs and isomiRs and their impact on human immunity to infectionhttps://www.biorxiv.org/content/10.1101/2020.01.31.928580v1 …
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Kaur Alasoo proslijedio/la je Tweet
How can we sort the wheat from the chaff of
#GWAS hits & find causal variants & genes for#Alzheimers?
Genomewide meta-analysis
Fine-mapping
Coloc
@jschwart37 et al tell us more in this latest#medRxiv preprint. W/@emblebi@sangerinstitute. https://www.medrxiv.org/content/10.1101/2020.01.22.20018424v1 …pic.twitter.com/1xKLVp5c4y
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Finally, if you want see how our results can be used to prioritise target genes for Alzheimer’s disease, check out the latest paper from
@jschwart37 https://www.medrxiv.org/content/10.1101/2020.01.22.20018424v1 … 9/9Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
This would not have been possible without the great team:
@kerimovOn,@dzerbino, James Hayhurst,@irenepapatheodo,@simonjupp,@DrP_stuff,@pinin4fjords,@TonyBurdett. Support from@targetvalidate,@emblebi and@UniTartuCS. 8/9Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
A subset of the results have already been integrated to the
@targetvalidate Genetics Portal (https://genetics.opentargets.org/ ). 7/9Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
All summary statistics can be downloaded by FTP or accessed via a REST API: http://www.ebi.ac.uk/eqtl/Data_access/ … 6/9
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We have mapped QTLs at the level of gene expression, exon expression, transcript usage, and promoter, splice junction and 3ʹ end usage. 5/9
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We have re-analysed raw gene expression and genotype data from 19 published eQTL studies (8,115 RNA-seq samples and 4,631 microarray samples from 4,685 unique donors). 4/9pic.twitter.com/iQUXedYpJh
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This is especially relevant for transcript-level and splicing QTLs where the results vary greatly depending on which reference annotations and quantification methods are used. 3/9
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A major hurdle in re-using published eQTL datasets to interpret GWAS results is that summary statistics are often unavailable of incomplete (e.g. missing betas, effect alleles or non-significant associations). 2/9
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We are extremely happy to present our latest work on setting up the
@eQTLCatalogue https://www.biorxiv.org/content/10.1101/2020.01.29.924266v1 … 1/9Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Kaur Alasoo proslijedio/la je Tweet
Great to see the first study using eQTL Catalogue summary statistics already published!https://twitter.com/jschwart37/status/1222196428828741634 …
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Kaur Alasoo proslijedio/la je Tweet
I'm excited to share our recent work on Alzheimer's disease - genetic meta-analysis followed by fine-mapping, coloc with QTL datasets, and network analyses to prioritize genes. Different lines of evidence reinforce prioritization.https://www.medrxiv.org/content/10.1101/2020.01.22.20018424v1 …
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Kaur Alasoo proslijedio/la je Tweet
Hello, world! If you are curious about our new data release, sign up for the
@emblebi webinar on Feb 12th, 3:30pm GMThttps://www.ebi.ac.uk/training/events/2020/eqtl-catalogue-compendium-uniformly-processed-human-expression-and-splicing-qtls …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Kaur Alasoo proslijedio/la je Tweet
Great talk from
@kauralasoo, reporting on the heroic work done applying for access and harmonising data from many sources to create the EQTL catalogue: http://www.ebi.ac.uk/eqtl/Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Kaur Alasoo proslijedio/la je Tweet
Excited to make use of the increasing number of open databases, including this eQTL catalogue and the recently launched
@PGSCataloghttps://twitter.com/emblebi/status/1218158918054174720 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Kaur Alasoo proslijedio/la je Tweet
Wonderful to see this finally out: an e/sQTL database
@emblebi spanning multiple studies, generated using a uniform pipeline. Great work from@dzerbino,@kauralasoo, and colleagues.https://twitter.com/emblebi/status/1218158918054174720 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Kaur Alasoo proslijedio/la je Tweet
Interested in the link between gene expression and splicing quantitative trait loci (
#QTL)? Check out our brand new eQTL Catalogue – a gateway to eQTL data from all available human studies#drugdiscovery@unitartu@sangerinstitute@targetvalidatehttps://www.ebi.ac.uk/about/news/press-releases/eQTL-catalogue …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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