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kakape's profile
Kai Kupferschmidt
Kai Kupferschmidt
Kai Kupferschmidt
Verified account
@kakape

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Kai KupferschmidtVerified account

@kakape

science journalist. molecular biologist. curious. contributing correspondent at @sciencemagazine part of @pandemiapodcast, all things #blue

Berlin, Germany
sciencemag.org/author/kai-kup…
Joined June 2009

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    1. Kai Kupferschmidt‏Verified account @kakape 23 Mar 2021

      Yesterday morning: great results from large trial of AZ‘s #covid19 vaccine Yesterday evening: DSMB „expressed concern that AstraZeneca may have included outdated information from that trial, which may have provided an incomplete view of the efficacy data“https://www.nih.gov/news-events/news-releases/niaid-statement-astrazeneca-vaccine …

      24 replies 176 retweets 441 likes
      Show this thread
    2. Kai Kupferschmidt‏Verified account @kakape 23 Mar 2021

      This whole pandemic is a rollercoaster I would like to get off, but AstraZeneca sure look like they are intent on sending us through a few extra loops and dips while we‘re on it...

      14 replies 43 retweets 469 likes
      Show this thread
    3. Kai Kupferschmidt‏Verified account @kakape 23 Mar 2021

      AstraZeneca have issued a statement on the DSMB’s concerns now incl. this beautiful example of clear crisis communication: "We have reviewed the preliminary assessment of the primary analysis and the results were consistent with the interim analysis."pic.twitter.com/GIEfIbSNJ3

      14 replies 43 retweets 224 likes
      Show this thread
    4. Kai Kupferschmidt‏Verified account @kakape 23 Mar 2021

      As far as I can parse this: Results yesterday were interim analysis based on data with cut-off point February 17. More up to date data is coming in form of the primary analysis within 48 hours and should not look all that different… Let’s wait and see…https://www.astrazeneca.com/media-centre/press-releases/2021/update-following-statement-by-niaid-on-azd1222-us-phase-iii-trial-data.html …

      5 replies 39 retweets 161 likes
      Show this thread
    5. Kai Kupferschmidt‏Verified account @kakape 23 Mar 2021

      Tony Fauci talking about this now on @GMA: DSMB "wrote a rather harsh note to them and with a copy to me saying that in fact they felt that the data that was in the press release, were somewhat outdated and might in fact be misleading a bit, and wanted them to straighten it out."

      2 replies 19 retweets 136 likes
      Show this thread
      Kai Kupferschmidt‏Verified account @kakape 23 Mar 2021

      Fauci: “It really is unfortunate that this happened. You know this is really what you call an unforced error, because the fact is, this is very likely a very good vaccine and this kind of thing does as you say do nothing, but really cast some doubt about the vaccines …"

      5:31 AM - 23 Mar 2021
      • 42 Retweets
      • 248 Likes
      • Edda Grabar Anita #vaccines-plus Special_K Kathrin Veronika 💙*WEAR A MASK*💙 Simons Elena 💙 Polly_makes 💙 Thanas Goga Alex Kaufman
      5 replies 42 retweets 248 likes
        1. New conversation
        2. Kai Kupferschmidt‏Verified account @kakape 23 Mar 2021

          “It was not necessary”, says Fauci. "If you look at it, the data really are quite good. But when they put it into the press release it wasn't completely accurate.”https://www.goodmorningamerica.com/news/video/fauci-discusses-concerns-oxfordastrazeneca-vaccine-data-76626319 …

          10 replies 75 retweets 231 likes
          Show this thread
        3. Kai Kupferschmidt‏Verified account @kakape 23 Mar 2021

          Fauci just called me as well and clarified the concerns: “It appears that they [AZ] may have been using the most favorable data, and the DSMB wanted to make sure that they corrected that..."

          9 replies 84 retweets 287 likes
          Show this thread
        4. Kai Kupferschmidt‏Verified account @kakape 23 Mar 2021

          He also clarified what happened with the press release: The NIH had modelled their press release announcing the results on the AZ press release. So when the DSMB raised concerns about that data, they felt they had to make this public too.

          4 replies 22 retweets 168 likes
          Show this thread
        5. Kai Kupferschmidt‏Verified account @kakape 23 Mar 2021

          Kai Kupferschmidt Retweeted Eric Topol

          A few noteworthy reactions. Here‘s @EricTopol first:https://twitter.com/EricTopol/status/1374366597171671048 …

          Kai Kupferschmidt added,

          Eric TopolVerified account @EricTopol
          This @AstraZeneca statement in response to the @NIH press release is unacceptable. They know exactly what is going on w/r to the time cutoff for 1° analysis, which appears to be at odds with the independent Data and Safety Monitoring Board. It should not take 48 hrs to sort out pic.twitter.com/cExD3kxfwi
          Show this thread
          1 reply 12 retweets 75 likes
          Show this thread
        6. Kai Kupferschmidt‏Verified account @kakape 23 Mar 2021

          Kai Kupferschmidt Retweeted Ashish K. Jha, MD, MPH

          And @ashishkjha:https://twitter.com/ashishkjha/status/1374351260191649794 …

          Kai Kupferschmidt added,

          Ashish K. Jha, MD, MPHVerified account @ashishkjha
          From everything I know, the AZ vaccine is a good vaccine that I would be comfortable having my family get From everything I know, AZ's incompetence at communicating trial results, working with regulatory agencies, etc. is stunning That's what we are seeing on display
          3 replies 9 retweets 90 likes
          Show this thread
        7. Kai Kupferschmidt‏Verified account @kakape 23 Mar 2021

          So, @washingtonpost has the letter that the DSMB sent to AZ and US officials and it looks like we may be talking about 69-74% efficacy for the vaccine instead of 79%. If that‘s true: Were those short-lived extra 5-10% really worth all this, AstraZeneca? https://www.washingtonpost.com/world/astrazeneca-oxford-vaccine-concerns/2021/03/23/2f931d34-8bc3-11eb-a33e-da28941cb9ac_story.html …pic.twitter.com/v5DQYqKbel

          20 replies 70 retweets 235 likes
          Show this thread
        8. Kai Kupferschmidt‏Verified account @kakape 23 Mar 2021

          Kai Kupferschmidt Retweeted Helen Branswell

          Also, always read @HelenBranswell (that goes for twitter too)...https://twitter.com/HelenBranswell/status/1374389008646557705 …

          Kai Kupferschmidt added,

          Helen BranswellVerified account @HelenBranswell
          1. Turning this into a thread about the extraordinary public rebuke of AstraZeneca today by the DSMB* of its US clinical trial. (*data & safety monitoring board, independent experts who oversee the trial & monitor the data) https://twitter.com/HelenBranswell/status/1374336969518514180 …
          Show this thread
          7 replies 14 retweets 77 likes
          Show this thread
        9. Kai Kupferschmidt‏Verified account @kakape 24 Mar 2021

          Hopefulley ending this thread here with the announcement by AstraZeneca that their newer data shows the vaccine to be 76% efficacious not 79% at preventing symptomatic #covid19.https://www.astrazeneca.com/media-centre/press-releases/2021/azd1222-us-phase-iii-primary-analysis-confirms-safety-and-efficacy.html …

          6 replies 14 retweets 61 likes
          Show this thread
        10. Kai Kupferschmidt‏Verified account @kakape 26 Mar 2021

          My awesome colleague @sciencecohen wrote a story yesterday about this whole AZ brouhaha and I will absolutely end this thread with a link to his story and this quote from it: "The company people shot themselves in the foot while the foot was in the mouth”https://www.sciencemag.org/news/2021/03/astrazeneca-lowers-efficacy-claim-covid-19-vaccine-bit-after-boards-rebuke …

          3 replies 23 retweets 91 likes
          Show this thread
        11. End of conversation
        1. New conversation
        2. Erika Herzog‏ @erikaherzog 23 Mar 2021
          Replying to @kakape

          Why is everything Dr. Fauci says so unclear and on the fence. It’s all very confusing. I wish he was a better communicator. And I wish Fauci would take a break from the full court press. It’s omnipresent - and also unhelpful as it stirs the pot unnecessarily.

          4 replies 0 retweets 4 likes
        3. toonarmycaptain‏ @toonarmycaptain 23 Mar 2021
          Replying to @erikaherzog @kakape

          He usually seems clear to me. I appreciate his candor in not reifying science and data, particularly on Covid where our days are so impacted, and our collective understanding is evolving day by day.

          1 reply 0 retweets 20 likes
        4. Show replies

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