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Julien Y. Dutheil proslijedio/la je Tweet
Great opportunity in the field of evolutionary genomics: a post doc position is available in our team at the Max Planck Institute for Evolutionary Biology to work on evolution of fungi. Check out: http://web.evolbio.mpg.de/envgen/stellenausschreibung_01.pdf …
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Wow, it's >15y that I'm doing statistics in R and only today I learned about "csvkit". Wake up from coma... or I should rather say, wake up from comma!
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Julien Y. Dutheil proslijedio/la je Tweet
Our review is now out in
@evoecology, with@jydutheil and Thomas Bataillon. We reviewed the methods used to infer the molecular adaptive rate and the determinants of adaptive evolution between species, within genomes, and within genes. https://doi.org/10.1007/s10682-019-10026-z …pic.twitter.com/GZt4Bam4l6
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Julien Y. Dutheil proslijedio/la je Tweet
iSMC is finally here! The much improved version our paper with
@natashapuzovic and@jydutheil is out in@PLOSGenetics. We develop a new model of the recombination landscape and show that it can infer recombination maps with a single pair of genomes:https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008449 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
"Greetings!! We would like to invite you to contribute a manuscript to be considered in the forthcoming issue of Journal of Textile Engineering and Fashion Technology." Maybe it's time to change that faculty picture...
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Now it's really autumn...
#basidiomycetes power!pic.twitter.com/RERVA2mIBS
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So in the end, we could describe here a very rare mutational event, catching it not long after it happened. And this simple event created two new gene variants: an inactivated HE (most likely becoming a pseudogene) and a (functional) truncated helicase. (10/10)
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...and the closest homolog of the HE is not found in the U. maydis mitogenome, but in one of its relative, another maize pathogen, S. reilianum, which diverged 20 My ago! ...HGT? (9/10)
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Other interesting things: the transfer seems to be quite recent, as we only see it is a few isolates... (8/10)
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Virulence and stress assays indicate a possible effect of the truncation in stress tolerance, but no direct effect on pathogenicity. (7/10)
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But it truncated the poor gene that was located there, a RecQ helicase that is most likely involved in telomere maintenance! (6/10)
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So, to make the story short, this selfish intron somehow escaped the mitochondrion and got inserted into the telomeric region of chr 9, where it got inactivated (5/10)
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Blast search revealed that the gene is similar to a homing endonuclease (HE), a selfish element that acts as an intron. They are commonly found in fungal (but not only) mitochondrial genomes, in particular, the cox1 gene (4/10)
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The GC content of U. maydis is very homogeneous along the nuclear genome, but UMAG_11064 has a clearly lower GC content... matching that of the mitochondrial genome (3/10)
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This story started (6 years ago!) with the codon usage analysis of the maize pathogen Ustilago maydis. One gene (with the fancy name of UMAG_11064) had a weird pattern: while nuclear, it displayed a clear mitochondrial codon usage (2/10)
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An old story finally coming out: the transfer of a mitochondrial selfish element to the nuclear genome and its consequences (with
@EvaStukenbrock) https://www.biorxiv.org/content/10.1101/787044v1 … (thread 1/10)Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
I really wonder who came with the term "coalescent with dust"... First I thought this was some kind of mathematician humour, but they seem pretty serious about it. Will try to fit in "dust-free n-lambda-coalescent at the next Xmas dinner"...
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Oh my...
@BegerowLab reporting the proposal to rename Ustilago maydis to Mycosarcoma maydis... I guess this is one of these cases where it would be easier to rename all other species!#fungal2019Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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Big congrats to
Bravo