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  1. proslijedio/la je Tweet
    prije 16 sati

    New preprint about choice predictive feedforward/back signals in V1 (). Joint work with an amazing group of people: , Florent Meyniel and Tobias Donner. And of course !

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  2. proslijedio/la je Tweet
    3. velj

    New out on ! \w , , Nicole de Ru & Sander Nieuwenhuis, we show that temporal expectation enhances perception by speeding up the the decision process onset without affecting its evolution! below (1/10)

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  3. proslijedio/la je Tweet
    31. sij

    Interested in decision-making, evidence accumulation, normative or circuit models, oscillations, cortical hierarchy, feedback, or brainstem arousal systems? Check out our new paper on ()! Led by , summary below. (1/11)

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  4. proslijedio/la je Tweet
    29. sij

    Today I will be teaching my undergrad course "How to build a brain from scratch" for the 2nd year running. I've put the materials online - include a document with all lecture slides and notes, which is about as long as a decent novel. Enjoy!

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  5. proslijedio/la je Tweet
    29. sij

    Updated our manuscript on viral manipulation of interneurons from mice to humans. Now with scATACseq-based enhancer selection and 4 new PV-specific enhancers with exquisite specificity for distinct regions of the brain :

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  6. proslijedio/la je Tweet
    24. sij

    Excited to share our latest work : mice display several key behavioral and neural signatures of visual spatial attention. Great job by , Full (open access) article! 👇

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  7. proslijedio/la je Tweet
    20. sij

    I'm very proud and excited to present to you: a team science approach to reproducibly studying decision-making! Want to know what it's been like to work on this? Behind-the-scenes 🧵👇 1/many

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  8. proslijedio/la je Tweet
    21. sij

    Modulation of Coordinated Activity across Cortical Layers by Plasticity of Inhibitory Synapses

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  9. proslijedio/la je Tweet
    9. sij

    New preprint! We made bright, tunable, far-red calcium and voltage indicators. Great collaboration between chemistry and protein engineering with and many others in the labs of and . Check it out!

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  10. proslijedio/la je Tweet
    9. sij

    I am super proud to share this work done in collaboration with Taylor Schmitz, Judes Poirier and Hermona Soreq, linking basal forebrain atrophy to neuroinflammation and amyloid/tau pathology in the very earliest stages of Alzheimer's disease

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  11. proslijedio/la je Tweet
    8. sij

    Mechanisms underlying gain modulation in the cortex

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  12. 2. sij
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  13. 2. sij

    11/11 In sum, when decisions are made in the face of uncertainty, tracking phasic arousal signals and the history of choices may be just as important for predicting choice behavior as tracking the objective evidence gathered from the outside world.

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  14. 2. sij

    10/11 We also found that evidence accumulation process is not only driven by the momentary evidence, bias, and arousal, but also by previous choices. :

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  15. 2. sij

    9/11 We also found that pupil-linked phasic arousal is recruited in relation to key computational variables such as and . :

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  16. 2. sij

    8/11 Repeating the same yes/no experiment during simultaneous MEG and pupillometry showed that the bias suppression is mediated by the arousal-related shaping of choice-predictive alpha-band activity in visual regions, including primary visual cortex.

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  17. 2. sij

    7/11 We then showed that the arousal-linked bias suppression in evidence accumulation is a general principle: it occurs in a range of decision-making tasks (across sensory domains and when based on memory) and across species (humans and mice). :

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  18. 2. sij

    6/11 Behavioral modeling indicated that subject’s evidence accumulation process was least biased on trials characterized by large pupil-linked arousal responses. :

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  19. 2. sij

    5/11 Repeating the same experiment during simultaneous fMRI and pupillometry showed that pupil dilation tracks task-evoked activity of some subcortical centers including the noradrenergic locus coeruleus, and cholinergic basal forebrain. :

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  20. 2. sij

    4/11 In my first study with , and we found that the pupil dilates during yes/no deliberations, and that the extent of dilation predicts the upcoming choice especially in subjects with strong prior biases. :

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