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Thanks to
@NIHprevents for the invitation and setting up this great webinar. This was great to give an overview of the role of the lung in RA etiology and outcomes@NIH_NIAMS@NIAIDFunding@RheumResearch@BrighamResearch Link: https://prevention.nih.gov/education-training/methods-mind-gap/epidemiologic-and-patient-oriented-research-methods-rheumatoid-arthritis-etiology-and-outcomes …https://twitter.com/Nephro_Sparks/status/1223006975706841088 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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These results offer more support that ACPA genesis may be intrinsically related to airway inflammation that contributes to a bi-directional association of obstructive lung disease and RA and helps explain excess respiratory mortality in seropositive RA
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While pre-RA women were 70% more likely to progress to asthma than controls, this risk was similar among pre-RA ACPA+ and pre-RA ACPA- women. So asthma may pre-dispose to ACPA elevation, but not differentially affect adult-onset asthma risk
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As an aside, we previously showed that women with incident seropositive RA were more likely to later develop COPD than matched controls, finely adjusting for the mediating effect of smoking after diagnosishttps://www.sciencedirect.com/science/article/abs/pii/S0049017217303827?via%3Dihub …
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Alternatively, it is possible that patients who go on to develop RA may clinically present in a COPD-like syndrome, perhaps as an extra-articular RA manifestation (maybe on the spectrum of bronchiectasis)
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When we only evaluated the pre-RA period (stopping follow-up at time of articular RA onset), we found that elevated pre-RA ACPA elevation increased COPD risk by 11-fold (!!!). This suggests that ACPA development may also relate to COPD pathogenesis beyond the effect of smoking.
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We found that women with pre-RA ACPA elevation had 3-fold increased risk of later developing COPD, even adjusting finely for smoking as continuous measure of smoking pack-years. In contrast, pre-RA ACPA- had no association with COPD
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In this study, we investigated risk for obstructive lung disease AFTER elevated pre-RA ACPA among 1,125 women in the Nurses' Health Studies (283 pre-RA and 842 matched controls)
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We previously showed that women with asthma were more likely to have elevated pre-RA ACPA and were more likely to progress to seropositive RA at clinical diagnosishttps://arthritis-research.biomedcentral.com/articles/10.1186/s13075-019-2035-3 …
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Therefore, individuals with elevated ACPA prior to clinical RA diagnosis may have airway mucosal injury that may manifest as obstructive lung disease
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Previous studies showed that ACPA elevations occur years prior to clinical RA onset perhaps at inflamed mucosa such as airways (or others such as gingiva, gut, or reproductive tracts)
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Our latest study is out linking elevation of anti-citrullinated protein antibodies (ACPA) in the preclinical rheumatoid arthritis (RA) period to chronic obstructive pulmonary disease (COPD) or asthmahttps://onlinelibrary.wiley.com/doi/abs/10.1002/acr.24140 …
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Jeff Sparks proslijedio/la je Tweet
worst hitting slump ever... “The incidence of NSF in patients with stage 4 or 5 CKD across all 16 studies was 0 of 4931.”https://jamanetwork.com/journals/jamainternalmedicine/articlepdf/2757311/jamainternal_woolen_2019_oi_190091.pdf …
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Jeff Sparks proslijedio/la je Tweet
Made my day to come home to a 10x14” cover photo of
@Nephro_Sparks. Thank you@KidneyNews@ASNKidneypic.twitter.com/v4fG7xvo8P
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Jeff Sparks proslijedio/la je Tweet
Upcoming
@RheumResearch app deadlines for 02/03: Need travel support for PRSYM? Apply! Wanting a preceptorship for the Summer? Apply! Health professional looking to take an online course? Apply! https://www.rheumresearch.org/awards-grantsHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Jeff Sparks proslijedio/la je Tweet
A critical mentor, and legend in
#rheumatology,#complement, and#immunology at@WUSTLmed where he was the long-time outstanding Chief@WUSTL_Rheum & Chair of Medicine: unveiling of Dr. John Atkinson’s portrait at the inaugural John P. Atkinson Lectureship. Congrats my friend!pic.twitter.com/fCgy42aDkm
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Join me this morning to hear about research methods investigating the lung in RA etiology and outcomes
@BrighamResearch@ACRheum@NIH_NIAMS@RheumResearchhttps://twitter.com/NIHprevents/status/1215273267482767360 …
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Jeff Sparks proslijedio/la je Tweet
I'm presenting tomorrow at the VERITY/SCS Seminar Series - 9am in BTM 02006B. My
@RheumResearch sponsored work - Latent Class Growth Analysis to Identify Rapid Structural Disease Progression in Knee Osteoarthritis. see u there :-) http://www.verityresearch.org/Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Dr Sonali Desai representing
@BrighamWomens rheumatology!https://twitter.com/BrighamWomens/status/1214933526577139713 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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