Jeff Sparks

@jeffsparks

Rheumatologist and Assistant Professor of Medicine at Brigham and Women's Hospital/Harvard Medical School performing epidemiologic and patient-oriented research

Boston, MA
Vrijeme pridruživanja: lipanj 2009.

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  1. 30. sij
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  2. 28. sij
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  3. 28. sij

    These results offer more support that ACPA genesis may be intrinsically related to airway inflammation that contributes to a bi-directional association of obstructive lung disease and RA and helps explain excess respiratory mortality in seropositive RA

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  4. 28. sij

    While pre-RA women were 70% more likely to progress to asthma than controls, this risk was similar among pre-RA ACPA+ and pre-RA ACPA- women. So asthma may pre-dispose to ACPA elevation, but not differentially affect adult-onset asthma risk

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  5. 28. sij

    As an aside, we previously showed that women with incident seropositive RA were more likely to later develop COPD than matched controls, finely adjusting for the mediating effect of smoking after diagnosis

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  6. 28. sij

    Alternatively, it is possible that patients who go on to develop RA may clinically present in a COPD-like syndrome, perhaps as an extra-articular RA manifestation (maybe on the spectrum of bronchiectasis)

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  7. 28. sij

    When we only evaluated the pre-RA period (stopping follow-up at time of articular RA onset), we found that elevated pre-RA ACPA elevation increased COPD risk by 11-fold (!!!). This suggests that ACPA development may also relate to COPD pathogenesis beyond the effect of smoking.

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  8. 28. sij

    We found that women with pre-RA ACPA elevation had 3-fold increased risk of later developing COPD, even adjusting finely for smoking as continuous measure of smoking pack-years. In contrast, pre-RA ACPA- had no association with COPD

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  9. 28. sij

    In this study, we investigated risk for obstructive lung disease AFTER elevated pre-RA ACPA among 1,125 women in the Nurses' Health Studies (283 pre-RA and 842 matched controls)

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  10. 28. sij

    We previously showed that women with asthma were more likely to have elevated pre-RA ACPA and were more likely to progress to seropositive RA at clinical diagnosis

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  11. 28. sij

    Therefore, individuals with elevated ACPA prior to clinical RA diagnosis may have airway mucosal injury that may manifest as obstructive lung disease

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  12. 28. sij

    Previous studies showed that ACPA elevations occur years prior to clinical RA onset perhaps at inflamed mucosa such as airways (or others such as gingiva, gut, or reproductive tracts)

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  13. 28. sij

    Our latest study is out linking elevation of anti-citrullinated protein antibodies (ACPA) in the preclinical rheumatoid arthritis (RA) period to chronic obstructive pulmonary disease (COPD) or asthma

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    worst hitting slump ever... “The incidence of NSF in patients with stage 4 or 5 CKD across all 16 studies was 0 of 4931.”

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    18. sij

    Made my day to come home to a 10x14” cover photo of . Thank you

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    17. sij

    Upcoming app deadlines for 02/03: Need travel support for PRSYM? Apply! Wanting a preceptorship for the Summer? Apply! Health professional looking to take an online course? Apply!

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    16. sij

    A critical mentor, and legend in , , and at where he was the long-time outstanding Chief & Chair of Medicine: unveiling of Dr. John Atkinson’s portrait at the inaugural John P. Atkinson Lectureship. Congrats my friend!

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  18. 16. sij

    Join me this morning to hear about research methods investigating the lung in RA etiology and outcomes

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    14. sij

    I'm presenting tomorrow at the VERITY/SCS Seminar Series - 9am in BTM 02006B. My sponsored work - Latent Class Growth Analysis to Identify Rapid Structural Disease Progression in Knee Osteoarthritis. see u there :-)

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  20. 9. sij
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