The "key differences" were in regions of the coronavirus spike protein that were the subject of genetic engineering experiments in labs around the world (mainly in the U.S. and China) for two decades.
“the SARS-CoV-2 virus has some key differences in specific genes relative to previously identified coronaviruses — the ones a laboratory would be working with. This constellation of changes makes it unlikely that it is the result of a laboratory 'escape’"https://www.livescience.com/coronavirus-wuhan-lab-complicated-origins.html …
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