Journal of Clinical Investigation

@jclinicalinvest

The JCI is a premiere venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine. Est. 1924 -

Ann Arbor, MI
Vrijeme pridruživanja: prosinac 2010.

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  1. In JCI Insight: Gut permeability, inflammation, and bone loss during menopause transition

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  2. Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α

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  3. Linear ubiquitin assembly complex regulates lung epithelial–driven responses during influenza infection

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  4. proslijedio/la je Tweet
    31. sij

    DYK rises in temps is linked to a rise in infectious diseases & heat related deaths?Read what Professors & wrote in about the dangers of bad heat waves & the need to drastically reduce carbon pollution

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    31. sij

    Very nice study from the Liddle lab showing that Piezo1-induced activation of leads to the development of ➡️

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  6. Breaking through the surface: more to learn about lipids and cardiovascular disease Echouffo-Tcheugui, Jain, and Cheng discuss the potential to use serum sphingolipid and ceramide measurements as cholesterol-independent biomarkers for CAD.

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  7. Underglycosylated prion protein modulates plaque formation in the brain Jason Bartz’s commentary discusses recent findings supporting further investigation of protein modification strategies as opportunities to modify prion disease progression.

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    30. sij

    ICYMI, a new study led by NIDDK researchers found that a drug activated brown fat, raised HDL cholesterol, and improved glucose metabolism in healthy women. Read more: ]

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  9. On : Warming temperatures could mean more heat-related illnesses and new diseases. and warn of climate change's negative effects on human health.

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  10. Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS

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  11. Oral immunotherapy tolerizes mice to enzyme replacement therapy for Morquio A syndrome

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  12. On the cover of : Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia

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  14. GABA interneurons are the cellular trigger for ketamine’s rapid antidepressant actions

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  15. The anti-IgE mAb omalizumab induces adverse reactions by engaging Fcγ receptors

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  16. Stable ischemic heart disease: how to keep it that way Leucker, Schulman, and Gerstenblith discuss the ISCHEMIA trial, which evaluated outcomes associated with invasive versus conservative management of ischemic heart disease. (Image: Wikimedia Commons)

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    29. sij

    Source of p53-reactive : Peripheral from patients with metastatic solid tumors

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  18. Prion protein glycosylation influences pathological plaque formation in mice

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  19. ICYMI: Mechanisms Underlying the Metabolic Syndrome This review series tackles the complex biology underlying the metabolic syndrome. The accompanying image, from Kahn et al., highlights heterogeneity within human adipose depots.

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  20. REVIEW: Biological basis for efficacy of activin receptor ligand traps in myelodysplastic syndromes Amit Verma et al. describe how these novel fusion proteins can mitigate pathologic overactivation of SMAD2/3 signaling in myelodysplastic syndromes.

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