Bloom Lab

@jbloom_lab

Lab studying molecular evolution of proteins and viruses. Affiliated with .

Vrijeme pridruživanja: lipanj 2014.

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  1. Prikvačeni tweet
    13. lip 2019.

    New work from our lab led by maps how flu can escape polyclonal human immunity: Watch the video abstract below for key findings (or read on in this Tweet chain):

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  2. 31. sij

    New anti-HIV antibody overcomes common resistance mutations, suppresses virus in mice as mono-therapy. Includes mutational antigenic profiling by in our group to map paucity of viral escape mutations relative to other VRC01-class antibodies:

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  3. proslijedio/la je Tweet
    29. sij

    The four patients in Germany no longer have symptoms. It seems they were only diagnosed because the company was alerted that a colleague visiting from China fell sick. This suggests many cases in China are asymptomatic and not reported.

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  4. proslijedio/la je Tweet
    28. sij
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  5. proslijedio/la je Tweet
    26. sij
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  6. proslijedio/la je Tweet
    25. sij

    Not sure what the is waiting for. We are above 1400 official cases. This is a PHEIC, we are all China at this moment. Not acting now will not age well.

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  7. proslijedio/la je Tweet
    25. sij

    The big takeaways remain the same as before: - Single or small number of animal-to-human spillover events in Nov - sustained human-to-human spread since this point - R0 between 1.5 and 3.5

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  8. proslijedio/la je Tweet
    25. sij

    Our latest report. Good evidence for sustained transmission in Wuhan prior to strong interventions. Worth emphasising: control doesn’t mean stopping all transmission. R0 ~2 means averting ~50% of infections for control.

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  9. proslijedio/la je Tweet
    25. sij
    Odgovor korisnicima i sljedećem broju korisnika:

    Latest estimates of H2H transmissibility of 2019-nCoV. Despite the enormous and admirable efforts in China and around the world, we need to plan for the possibility containment of this epidemic isn’t possible

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  10. 20. sij

    Work by inferring site-specific models. Shows most models underestimate long branches, partial solution for large alignments. Like prior work (including our own), no magic bullet. But those working on deep viral phlogenetics should be aware of issues explained here.

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  11. proslijedio/la je Tweet
    13. sij

    Good morning Seattle! Our 1/2 inch if snow has delayed until 10:15. Please check the website for more details.

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  12. proslijedio/la je Tweet
    13. sij

    More bad news for us ‘middle-aged’ people: some of us might be in a perpetual state of H3N2 influenza virus susceptibility due to our immune histories from the 1970s. A new preprint from our lab with modeling from :

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  13. proslijedio/la je Tweet
    10. sij

    Thanks for featuring our Deep Mutational Scanning symposium (Jan. 13-14) and guests on your Health Tech podcast!

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  14. proslijedio/la je Tweet
    8. sij

    Maternal antibodies are awesome but they can inhibit de novo immune responses elicited by vaccines. In this paper, we identified a nucleic acid-based vaccine that can slip under the radar of maternal antibodies and elicit good antibody responses.

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  15. proslijedio/la je Tweet
    2. sij

    student final paper from his PhD was published over the winter break. Abs targeting conserved RBS of H3 can be elicited by vaccination, but they are rare. Collaboration with , , et al

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  16. proslijedio/la je Tweet
    1. sij

    A potential challenge for universal flu vaccine development: H3 but not H1 can readily escape two of the best HA stem antibodies. Nice collaboration between , , Wen Su, Hui-Ling Yen, and folks at

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  17. proslijedio/la je Tweet
    30. pro 2019.

    Informative and critical discussion of ancient viral work from , , and Measles may have emerged when large cities rose, 1500 years earlier than thought

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  18. proslijedio/la je Tweet
    18. pro 2019.

    Congrats to on defending her thesis today at ! Best of luck to her on a promising career. Next step, postdoc in at the Hutch! And Happy Birthday!

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  19. proslijedio/la je Tweet

    Huge congratulations to Kate Dusenbury from for receiving an F30 grant from the National Institute of Allergy and Infectious Diseases ()!

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  20. proslijedio/la je Tweet
    13. pro 2019.

    Kate Dusenbury has been awarded an F30 from the NIAID.

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  21. 12. pro 2019.

    (5/5) Both reviewers looked carefully at the actual code, and even made a pull request with some of his reviews to improve the package! Anyone looking for ideas of how to actually make scientific publishing work better should look at .

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