Wow!
"Why did the researchers test two different doses?
It was a lucky mistake. Researchers in Britain had been meaning to give volunteers the initial dose at full strength, but they made a miscalculation & accidentally gave it at half strength..."
nytimes.com/2020/11/24/hea
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Reading the article now but that's a pretty huge mistake for a clinical trial (I'm guessing it was during clinical trials, but I'll RTFA and find out).
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Ok, this is a major WTF moment for me:
"Surprisingly, the vaccine combination in which the first dose was only at half strength was 90 percent effective at preventing Covid-19 in the trial. In contrast, the combination of two, full-dose shots led to just 62 percent efficacy."
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Yeah, the trial raised a bunch of interesting, impt q's. As per immunologists/vaccinologist, lower 1st dose may have overcome a common immune response in 1st dose in a way that can limit efficacy. Also, impact of COVID19 prevalence where trial arms were located.
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On a more general scale, I'm always fascinated how research mistakes can lead to amazing discoveries. You are a sociologist -- can you think of any famous research mistakes in your field that lead to interesting discoveries?
This wasn't necessarily a mistake, but I was always fascinated by the Milgram Shock Experiment. Would something like that ever get pass an IRB? I sincerely doubt it -- My guess is that such an experiment would be viewed as unethical. Similar to the Stanford (?) prison experiment
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Oh yeah. It is basically used as a textbook example in ethics training.
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Good q. I know they exist, but med. ones (or at least unanticipated effects) come to mind for me: Sildenafil (Viagra) heart trial pts keeping unused pills; Minoxidil for high BP pts showing hair growth. Then, natural experiments offering... 1/
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2/2 chance to examine something impt. E.g., Costello & colleagues' study of youth mental hlth in NC--btwn waves, one of the study communities opened an Am. Indian casino with extensive inc. distribution plan, enabling chance to test q's abt impact of income on youth.
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