Wow!
"Why did the researchers test two different doses?
It was a lucky mistake. Researchers in Britain had been meaning to give volunteers the initial dose at full strength, but they made a miscalculation & accidentally gave it at half strength..."
nytimes.com/2020/11/24/hea
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Reading the article now but that's a pretty huge mistake for a clinical trial (I'm guessing it was during clinical trials, but I'll RTFA and find out).
Ok, this is a major WTF moment for me:
"Surprisingly, the vaccine combination in which the first dose was only at half strength was 90 percent effective at preventing Covid-19 in the trial. In contrast, the combination of two, full-dose shots led to just 62 percent efficacy."
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Yeah, the trial raised a bunch of interesting, impt q's. As per immunologists/vaccinologist, lower 1st dose may have overcome a common immune response in 1st dose in a way that can limit efficacy. Also, impact of COVID19 prevalence where trial arms were located.
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