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james lynch proslijedio/la je Tweet
Feeling honored that our
@NatureMedicine paper describing the undulations of the aging plasma proteome has been so well received. https://www.nature.com/articles/s41591-019-0673-2 … I’ll summarize the main findings in this thread!pic.twitter.com/YzesmKtYkq
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thank you to all for this impressive information - we are one step closer to solving the aging puzzlehttps://twitter.com/jpsenescence/status/1194646584828534784 …
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due to the significant risks involved, disclosure via social media has been decided against, but half of the current followers have received contact info & 100% of requests for more info have been granted
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not wanting it to be overlooked, ICPHAM is conducting a long term exploratory experiment on one test subject (begun 1999 to 2019 so far, dosages every 4 hours) no clear positive or negative result has been demonstrated so far
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in present day, it is mentioned in Endocrinology texts but is given little attention (with a little effort, experts should be able to identify it)
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so this cell to cell communicator was assumed to be of little importance despite the fact that it is present in large quantities in young adult humans (it declines with age)
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most of the scientific community of a quarter century ago concluded that no benefit in mice = probably no benefit in humans
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this results in no benefit in mice. experiments performed in mice have demonstrated disappointing negative results
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evidence suggests that mice, having evolved without this cell to cell communicator, have evolved without the receptors as well
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ICPHAM = Investigating Cell to cell communicators Present in Humans but Absent in Mice
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thanks for passing on this important infohttps://twitter.com/wysscoray/status/1168233008198848513 …
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#PLOSONE: Longitudinal effects of aging on plasma proteins levels in older adults – associations with kidney ...http://dx.plos.org/10.1371/journal.pone.0212060 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
thank you for this impressive work. one of the greatest challenges remains the lack of universally agreed biomarkers. while this biomarker is non modifiable, it may prove to be useful.https://twitter.com/Joris_Deelen/status/1161588333375631362 …
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the "best guess" of this investigator is that the cell to cell communicator may impact longevity, but has little to no impact on neural functions
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since the cell to cell communicator is present in humans, but absent in mice, areas in which the 2 species differ may be impacted
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while an early exploratory experiment is suggestive, the mechanism of it's action remains unknown
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experiments with mice have demonstrated no benefit, but experiments with humans remain inconclusive
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evidence suggests that mice, having evolved without this cell to cell communicator, have evolved without the required receptors as well
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after a quarter century of working on this project, i have found only one cell to cell communicator that matches this criteria
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ICPHAM project = Investigating Cell to cell communicators Present in Humans but Absent in Mice
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