Unfortunately, forensic epidemiology tends to bottom out before finding the first animal-human contact, be it in a lab, on a farm, at a slaughterhouse, or in a bushmeat market. The best thing we can do is enforce sanitary protocols based on updated risk assessments.
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This might actually happen, for example, if the US congress sets new HVAC standards to minimize the spread of disease. Or if the WHO sets more stringent guidance for gain of function research. If you have to do this stuff, do it in the actual BSL4 part of the lab. Easy. Done.
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Such improvements have been made in the past. The US has standards to ensure wildlife and livestock are kept apart, for instance, to prevent another Spanish Flu. If prion diseases start to break out in humans, it may have to ban deer hunting.
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Cholera has killed tens of millions worldwide since the first pandemic in... 1817. Until then outbreaks were almost entirely confined to India. Massive human intervention was required to make cholera into the menace it became.
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