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jackfruitstaken's profile
JF
JF
JF
@jackfruitstaken

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JF

@jackfruitstaken

Jackfruit from the Internet. "Ein Tier, das nur in der Gesellschaft sich vereinzeln kann." - Marx "Blam[es] on his boots the faults of his feet." - Beckett

Joined June 2009

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    1. Trevor Bedford‏Verified account @trvrb 6 Mar 2020

      There is continued interest in "L" vs "S" strains of #SARSCoV2 proposed in the manuscript https://academic.oup.com/nsr/advance-article/doi/10.1093/nsr/nwaa036/5775463 …. Please consider this thread to be a public peer review of this work. 1/8

      47 replies 625 retweets 1,375 likes
      Show this thread
    2. Trevor Bedford‏Verified account @trvrb 6 Mar 2020

      We've recorded 145 different single amino acid mutations among sequenced viruses in the #COVID19 pandemic. This manuscript focuses on a particular change from leucine ("L") to serine ("S") at site 84 in the ORF-8 gene of #SARSCoV2. 2/8

      2 replies 42 retweets 167 likes
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    3. Trevor Bedford‏Verified account @trvrb 6 Mar 2020

      This mutation appears to have happened very early on in the outbreak while the virus was still in Wuhan, China. Viruses with "L" and viruses with "S" have spread from Wuhan to the rest of the world. Visible at https://nextstrain.org/ncov?c=gt-ORF8_84&r=country …. 3/8pic.twitter.com/L4zTNTxSa9

      4 replies 81 retweets 233 likes
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    4. Trevor Bedford‏Verified account @trvrb 6 Mar 2020

      Generally, the expectation among virologists is that a random single amino acid change will have little impact on virus behavior. My "null" model would be that this mutation just happened to occur on an early branch on the tree and any "impact" is due solely to epidemiology. 4/8

      2 replies 25 retweets 174 likes
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    5. Trevor Bedford‏Verified account @trvrb 6 Mar 2020

      We had a similar story with Ebola virus in West Africa where a possibly impactful mutation occurred, but distinguishing between virological and epidemiological effects was hugely difficult. https://bedford.io/papers/bedford-ebola-gp82-adaptation/ … 5/8

      2 replies 22 retweets 154 likes
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    6. Trevor Bedford‏Verified account @trvrb 6 Mar 2020

      Trevor Bedford Retweeted Richard Neher

      Any differences in apparent severity between these two genetic variants are most likely due to sampling of market-associated severe cases in Wuhan and missing the bulk of mild cases in this setting. 6/8https://twitter.com/richardneher/status/1235217967727681536 …

      Trevor Bedford added,

      Richard Neher @richardneher
      A recent paper claims that #SARSCoV2 split into L and S strains with L leading to more severe #COVID19. This is most likely a statistical artifact due to intense early sampling of the "L" group in Wuhan, resulting in higher apparent CFR in this group. [1/3]
      Show this thread
      5 replies 62 retweets 246 likes
      Show this thread
    7. Trevor Bedford‏Verified account @trvrb 6 Mar 2020

      That said, we will continue to monitor spread of these two variants to look to see how frequencies behave over time and to look for possible differences in clinical outcomes, though at this point we don't see one variant outcompeting the other. 7/8pic.twitter.com/ozvjIYyufU

      3 replies 46 retweets 249 likes
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    8. Trevor Bedford‏Verified account @trvrb 6 Mar 2020

      In summary, I don't think the strong conclusions of the manuscript are warranted. We will monitor these two genetic variants, but I see no reason to conclude they have important functional significance at this point. 8/8

      23 replies 78 retweets 640 likes
      Show this thread
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      JF‏ @jackfruitstaken 6 Mar 2020
      Replying to @dekkagaijin @trvrb

      What a jerk! 😂

      6:45 PM - 6 Mar 2020
      • 1 Like
      • Clouds MacEngie
      0 replies 0 retweets 1 like

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