prion is basically a misfolded protein state which can somehow propagate it's misfolded state to other similar proteins
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Replying to @i_contemplate_ @pashyaka
to start this, imp to remember that each protein has a specific sequence of amino acids in its chain. this sequenc
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forms a chain which then usually folds into its native state or a very specific conformation, so each protein has
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exactly one native state. prion proteins are a misfolded sequence which form another form, diff from the native
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state. so in short what happens is when the properly folded protein molecule comes in contact with the misfolded
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structure, there are disruptions in its molecular structure cause by atomic interactions with the misfolded versio
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which cause the properly folded protein to misfold and assume the same state the misfolded protein is in. kinda
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like a fresh fruit becoming rotten by coming in close contact with rotten fruits. exact mechanism is still as yet
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not properly understood. but u might start reading this here for brief overview http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142357/ …
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@NCBI ah thanks. Makes sense!
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