Preprint produced by the Cornell ENID Center now available. Describes single cell RNA sequencing of immune cells, which identifies classical monocytes as highly dysregulated in ME/CFS subjects vs sedentary controls tinyurl.com/4e7cdeum
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If platelets are involved in PEM then maybe aspirin can reduce the severity of PEM.
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G6PD Deficiency persons often can not use aspirin safely
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This is a wonderful study! 2 questions:
1. If platelets are getting improperly activated after exercise, could that activate the immune system and causes feelings of malaise?
and ...
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2. Could platelets be activated by eATP released by erythrocytes suffering shear stress (following Scheinbenbogen's theory of insufficient vasodilation)?
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Triple anticoagulation hasn’t had a significant effect on my symptoms or PEM. Dual antiplatelet therapy prior had no effect on my symptoms or PEM whatsoever.
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Could your findings of ⬆️CCL4 expression be a possible link to #neuroinflammation in ME/CFS as the CCL4 pathway may disrupt BBB and may ⬆️ immune cell trafficing into the CNS?
pubmed.ncbi.nlm.nih.gov/24047524/
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Not if "no lasting damage" is a viable hypotheses, I am afraid! 😄
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