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2/ New study by et al shows that #MECFS patients have metabolic defects that cannot be explained by exercise phobias, deconditioning or 'illness beliefs'
#pwME have reduced oxygen consumption during exercise tests
buff.ly/2CXH6Hj
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3/ #pwME have an impaired ability to increase their oxygen consumption during exercise
This is entirely different to every other disease we know including cardiovascular disease, lung disease, end-stage renal disease, hypertension & cystic fibrosis
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4/ And #MECFS patients also show impaired oxygen consumption and reduced anaerobic threshold compared to Multiple Sclerosis
#MECFS are #SickNotDeconditioned, #SickNotTired, #SickNotWeak
onlinelibrary.wiley.com/doi/abs/10.111
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5/ Exercise testing provides an explanation for why #MECFS patients can crash even after modest exertion
The reduced aerobic capacity of #pwME results in a switch to anaerobic #metabolism that likely impacts their ability to do simple daily activities
frontiersin.org/article/10.338
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6/ And #MECFS patients can 'crash' if they over-exert resulting in a post-exertional malaise #PEM
Triggering #PEM reduces the threshold at which anaerobic #metabolism accelerates which impairs the ability of patients to do non-strenuous tasks
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9/ Exercise studies also show that the increased reliance on anaerobic #metabolism in #MECFS patients results in increased metabolites such as lactic acid which likely leads to an inability to maintain work and a reduction in activity
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This review by discusses how cardiopulmonary exercise testing #CPET can be used to help diagnose & research #MECFS
This table provides a helpful list definitions for patients and doctors to investigate #MECFS
#MedEd #MedTwitter
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